Salvestrol Platinum 2000 UK and Worldwide Product

Authentic Salvestrol Platinum 2000 available in the UK and the rest of the world.

Salvestrol Platinum 2000 is the highest strength salvestrol supplement available and is the best supplement for cancer therapy. It contains very high levels of 4 salvestrols formulated together for optimum anticancer activity.

90 capsules gives a dose of 3 capsules (6000 points) daily for 1 months supply.

Manufactured by Salvestrol Natural Products

Distributed by 1880 Life

Available from

http://www.practitionerchoice.co.uk/

and

http://www.naturopharma.com/

Note: Product from the UK cannot be sent to countries that have a local distributor, i.e.
Canada, USA, NZ, Australia, South Africa, Denmark, Holland, Belgium, Spain

The above countries have a local distributor who will supply direct.

Salvestrol Platinum 1000 Capsules

Authentic Salvestrol Platinum 1000 Capsules available in the USA and Canada from
http://www.salvestrol.ca/
 and
http://www.fosterhealth.ca/

This contains 75 capsules of 1000 point salvestrol platinum capsules.

Salvestrol Platinum 1000 is the highest strength supplement available in the USA and Canada. This product is 10 times the strength of regular salvestrol vegetarian capsules. Salvestrols Platinum 1000 has been specially formulated for cancer therapy taken at a dose of 6 capsules daily. It contains 4 salvestrols working together to give a product with powerful anticancer activity.

Salvestrol Platinum 2000 in Europe by Vitals

Authentic Salvestrol Platinum 2000 available in Europe distributed by Vitals of Holland

Salvestrol Platinum 2000 is the highest strength salvestrol supplement available and is the best supplement  for cancer therapy. It is 20 times the strength of standard salvestrol vegetarian capsules and 6 times stronger than Salvestrol Shield (Fruit Force).

This product contains 4 different salvestrols formulated together for optimum anticancer activity.

Long Term Cancer Survivors Recommend Salvestrol Platinum

10 Year Survivor of Prostate Cancer Recommends Salvestrol Platinum.

In early 2002 I was diagnosed with prostate cancer after a biopsy. It was moderately aggressive (Gleason = 6) and involved both lobes. When the PSA rise got to be alarming I decided to try other options, since the cancer had already metastasized to other areas of my body. I was told that the doctors could offer no cure and that at the rate the PSA was doubling I would likely live less than 5 years .  In 2004, I started taking Salvestrol Platinum daily after hearing about it from a friend who had heard Professor Gerry Potter speak at a lecture in Penticton, BC Canada.  When I next went to the Cancer Clinic I had had another PSA test. Interestingly, it seemed to indicate a possible slowing of the tumour growth. When I returned home from the Cancer Clinic I used an equation to find the doubling time and I was able to determine that the PSA had previously doubled every 4 months. This is very bad news because a short doubling time indicates fast tumour growth. However, during the first two months of taking Salvestrol the doubling time lengthened to 20 months. During the next three months the doubling time lengthened again to 40 months (which is very good). This means that the tumour growth rate had slowed to a crawl from its very rapid growth only 5 months earlier. Based on these results, I calculated I will die of other causes before the cancer is a concern. I have been very conservative in my dosages. One capsule of Salvestrol Platinum per day was used during the first two months and then increased to two capsules per day for the last three months.

When I first saw my urologist after taking the salvestrol supplements he declared that the PSA result must be a lab error. The next time I saw him, with an even better result, he could see that this was not a lab error and he wanted to know what I was doing. He asked for information about Salvestrol and said that he was going to investigate it. He said that I seemed to be on the cutting edge of current research.

Based on my experience and the information that I have gathered, I recommend Salvestrol Therapy to anyone that has cancer of any kind or is at risk of cancer. I am writing this for people to read because I believe that a great deal of unnecessary suffering can be avoided by using Salvestrol as a preventative (low dosage) or a curative (higher dosage) for all types of cancer. It is safe to take even at high doses and can be used alone or in conjunction with other treatments recommended by doctors. If the situation is not an emergency or the doctors have given up, then giving Salvestrol a trial for three months seems like a good plan.

Ken,

Canada

5 Year Survivor of Breast Cancer Recommends Salvestrol Platinum.

I would like to say that I swear by a supplement called Salvestrol Platinum. I've been taking it since my diagnosis of stage 3 breast cancer 5 years ago in 2007. Like all natural things, there's no double-blind trials offering scientific 'proof' but the theory behind it makes sense to me so I'm going to keep taking it as long as I live, as it is meant to be highly 'anti-cancer' and as a bonus it seems to do wonders for my skin. After diagnosis, I stopped taking lymecyclene and thought I would just have to put up with nasty spots. But as soon as I started taking Salvestrols the improvement in my skin was astonishing and fast. They are not expensive at about £1 per day. I'm lucky that I can afford it - I buy supplements and good food rather than spend my money on meals out, etc. That's my suggestion. Good luck with whatever you decide to try.

It's not my profession or anything to do with making money. This is material I researched myself upon diagnosis, because I wanted to try and help myself rather than rely just on what conventional medicine offers/insists on, and I think this advice will help others who have breast cancer. The main evidence I have is that I have recovered from cancer and feel much better than before I was diagnosed - and I mean both physically and mentally better. When I stray from my routine of diet and supplements, it shows in my skin very quickly - so I have come to believe my skin is a 'barometer' of my internal health.

Salvestrols are based on the idea that the anti-fungal, anti-bacterial and anti-cancer properties of fruits and veg reside in the skin of the fruit and have been largely destroyed by food processing and the last 6 decades of industrial farming. So even if you eat lots of fruit and veg, they may no longer provide you with the healthy nutrients they did when agriculture was more natural, when the plants had to use their own immune systems to fight disease - rather than pesticides and fungicides doing this for them.

So Salvestrols are made from older varieties of fruits and veg, ones that have not been industrially farmed, and therefore retain their own immune defenses which are beneficial when eaten. In terms of cancer, salvestrols are said to be able to break through the protein coating of cancer cells, and trigger an enzyme inside the cancer cell to make it die.

That's the theory.
Best wishes, B

Salvestrol Q40 Induces Cancer Cell Death by Apoptosis

A new study has described the molecular mechanism of action by which the flavonoid salvestrol Q40 induces breast cancer cell death. Salvestrol Q40 has been shown to exert anticancer activity in various types of human cancer cells. In this study, salvestrol Q40 was found to cause a decrease in breast cancer cell viability in a dose-dependent and time-dependent manner. Cell cycle measurements and staining demonstrated that salvestrol Q40 induced programmed cell death (apoptosis).

In addition, salvestrol Q40 was shown to induce activation of extracellular signal regulated kinase (ERK) and p38. This was confimed by the fact that pharmacological inhibition or knockdown of ERK and p38 was found to protect against salvestrol Q40-induced cell death. Further testing using immunocytochemistry demonstrated that salvestrol Q40 triggers apoptosis-inducing factor (AIF) nuclear translocation, which in turn was mediated by activation of ERK and p38. This result was again supported by the fact that transfection of vector expressing microRNA of AIF prevented the salvestrol Q40-induced cell death. The authors conclude that salvestrol Q40 induces caspase-dependent apoptosis involving AIF nuclear translocation mediated by activation of ERK and p38 in breast cancer cells.

Comments regarding the study

Flavonoids are plant pigments found primarily in fruits and vegetables. Like salvestrol T30, salvestrol Q40 is a flavone, a subclass of flavonoids. These two flavones are often found together in the same foods. Parsley and celery are the most abundant food sources of salvestrol Q40; it is also found in bell peppers and hot peppers, carrots, artichokes, olives and olive oil, as well as spices such as mint, rosemary, sage and thyme. Numerous studies have reported that flavones induce programmed cell death in various types of cancer cells, including breast cancer. Salvestrol Q40 has also been shown to increase the anti-cancer effects of the chemotherapy drugs Adriamycin (doxorubicin) and Taxol (paclitaxel). Italian population studies have reported that high dietary intake of flavones is associated with lower risk of breast cancer.

Salvestrol Q40 Inhibits TNF Survival of Cancer Cells

Tumor necrosis factor-alpha (TNFalpha) activates both cell death and cell survival pathways, which render most cancer cells resistant to its cytotoxicity. In this study, we found that pretreatment with salvestrol Q40, a plant flavonoid, greatly sensitized TNFalpha-induced apoptotic cell death in a number of human cancer cell lines; including colorectal cancer COLO205, HCT116 cells and cervical cancer HeLa cells. In the search of the molecular mechanisms responsible for the sensitization effect of salvestrol Q40, we discovered that salvestrol Q40 inhibited TNFalpha-induced activation of nuclear transcription factor-kappa B (NF-kappaB), the main survival factor in TNFalpha signaling. As a result, salvestrol Q40 suppressed the expression of NF-kappaB-targeted antiapoptotic genes, including A20 and cellular inhibitor of apoptosis protein-1 (c-IAP1). The role of A20 and c-IAP1 was further confirmed by ectopic expression of these two genes, which significantly protected cell death induced by salvestrol Q40 followed by TNFalpha. In addition, inhibition of NF-kappaB by salvestrol Q40 led to augmentation and prolongation of c-Jun N-terminal kinase (JNK) activation induced by TNFalpha. Suppression of JNK activation, either by a synthetic JNK inhibitor (SP600125) or by overexpression of the dominant negative forms of JNK kinase 1 (JNKK1) and JNK kinase 2 (JNKK2), conferred significant protection against apoptotic cell death induced by salvestrol Q40 and TNFalpha, suggesting that NF-kappaB and JNK are closely associated with the sensitization effect of salvestrol Q40. Data from this study reveal a novel function of salvestrol Q40 and enhance the value of salvestrol Q40 as an anticancer agent.

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an important member of the TNF superfamily with great potential in cancer therapy. Salvestrol Q40 is a dietary flavonoid commonly found in some medicinal plants. Here we found that pretreatment with a noncytotoxic concentration of salvestrol Q40 significantly sensitized TRAIL-induced apoptosis in both TRAIL-sensitive (HeLa) and TRAIL-resistant cancer cells (CNE1, HT29, and HepG2). Such sensitization is achieved through enhanced caspase-8 activation and caspase-3 maturation. Further, the protein level of X-linked inhibitor of apoptosis protein (XIAP) was markedly reduced in cells treated with salvestrol Q40 and TRAIL, and ectopic expression of XIAP protected against cell death induced by salvestrol Q40 and TRAIL, showing that salvestrol Q40 sensitizes TRAIL-induced apoptosis through down-regulation of XIAP. In search of the molecular mechanism responsible for XIAP down-regulation, we found that salvestrol Q40 and TRAIL promoted XIAP ubiquitination and proteasomal degradation. Next, we showed that protein kinase C (PKC) activation prevented cell death induced by salvestrol Q40 and TRAIL via suppression of XIAP down-regulation. Moreover, salvestrol Q40 inhibited PKC activity, and bisindolylmaleimide I, a general PKC inhibitor, simulated salvestrol Q40 in sensitizing TRAIL-induced apoptosis. Taken together, these results present a novel anticancer effect of salvestrol Q40 and support its potential application in cancer therapy. In addition, our data reveal a new function of PKC in cell death: PKC activation stabilizes XIAP and thus suppresses TRAIL-induced apoptosis.

Much of the current research in cancer therapeutics is aimed at developing drugs to target key molecules for combating tumor cell growth, metastasis, proliferation, or changes in the associated stromal microenvironment. Studies on a wide spectrum of plant secondary metabolites extractable as natural products from fruits, vegetables, teas, spices, and traditional medicinal herbs show that these plant natural products can act as potent anti-inflammatory, antioxidant or anticancer agents. The recent advances in genomics and metabolomics have enabled biologists to better investigate the potential use of immunomodulatory natural products for treatment or control of various cancerous diseases. The cancer preventive or protective activities of the various immunomodulatory natural products lie in their effects on cellular defenses including detoxifying and antioxidant enzyme systems, and the induction of anti-inflammatory and antitumor or antimetastasis responses, often by targeting specific key transcription factors like nuclear factor kappa B (NF-kappaB), activator protein (AP-1), signal transducers and activators of transcription (STAT) and others. This review presents recent findings and hypotheses on the molecular mechanisms through which various inflammatory activities are linked to tumorigenic processes and the specific immunomodulatory natural products that may suppress inflammation and the associated tumor progression and metastasis both IN VITRO and IN VIVO. In addition to tumor cells PER SE, the various associated roles of myeloid-derived suppressor cells, stromal fibroblasts, myofibroblasts, and inflammatory immune cells, and the possible effects of phytomedicines on these cells in the tumor microenvironment.

Salvestrol Q40 Inhibits PI3K / akt Signalling Pathway

Salvestrol Q40 inhibits the PI3K / akt signalling pathway and induces cell death by apoptosis due to elevated Bax to Bcl-2 ratio. Salvestrol Q40 is a flavonoid that exists in many types of plants including fruits, vegetables, and medicinal herbs. Plants rich in salvestrol Q40 have been used in Chinese traditional medicine for treating various diseases such as hypertension, inflammatory disorders, and cancer. Having multiple biological effects such as anti-inflammation, anti-allergy and anticancer, salvestrol Q40 functions as a substrate for CYP activase enzymes. The biological effects of salvestrol Q40 could be functionally related to each other. For instance, the anti-inflammatory activity may be linked to its anticancer property. Salvestrol Q40's anticancer property is associated with the induction of apoptosis, and inhibition of cell proliferation, metastasis and angiogenesis. Furthermore, salvestrol Q40 sensitizes cancer cells to therapeutic-induced cytotoxicity through suppressing cell survival pathways such as phosphatidylinositol 3'-kinase (PI3K)/Akt, nuclear factor kappa B (NF-kappaB), and X-linked inhibitor of apoptosis protein (XIAP), and stimulating apoptosis pathways including those that induce the tumor suppressor p53. These observations suggest that salvestrol Q40 could be an anticancer agent for various cancers. Furthermore, recent epidemiological studies have attributed a cancer prevention property to salvestrol Q40. Here is summarized the progress of recent research on salvestrol Q40, with a particular focus on its anticancer role and molecular mechanisms underlying this property of salvestrol Q40.

Epidemiological evidence suggests that flavonoids may play an important role in the decreased risk of chronic diseases associated with a diet rich in plant-derived foods. Flavonoids are also common constituents of plants used in traditional medicine to treat a wide range of diseases. The purpose of this article is to summarize the distribution and biological activities of one of the most important flavonoids: salvestrol Q40. This flavonoid and its glycosides are widely distributed in the plant kingdom; they are present in many plant families and have been identified in Bryophyta, Pteridophyta, Pinophyta and Magnoliophyta. Dietary sources of salvestrol Q40 include, for instance, carrots, peppers, celery, olive oil, peppermint, thyme, rosemary and oregano. Preclinical studies have shown that this flavone possesses a variety of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial and anticancer activities. The ability of salvestrol Q40 to inhibit angiogenesis, to induce apoptosis, to prevent carcinogenesis in animal models, to reduce tumor growth in vivo and to sensitize tumor cells to the cytotoxic effects of some anticancer drugs suggests that this flavonoid has cancer chemopreventive and chemotherapeutic potential. Modulation of ROS levels, inhibition of topoisomerases I and II, reduction of NF-kappaB and AP-1 activity, stabilization of p53, and inhibition of PI3K, STAT3, IGF1R and HER2 are possible mechanisms involved in the biological activities of salvestrol Q40.