will one tablet a day help treat early stage colon cancer, no mets very small in size in pet scan. or should this be increased to 2 or 3 tablets per day?
The recommended dose for colon cancer is 3 capsules daily. It will work at 1 capsule daily but the response is slower.
Hi thanks for the information as I am adding this to what is already a large supplement protocol for one of my clients at this stage I think it would be best to add 1 Platinum capsule for the first week the use 1 platinum capsule twice a day for the second week then staying on a dose of 1 Platinum capsule 3 times per day. I have also dropped the Trans-Resveratrol as I have read resveratrol may block this product from working. I assume there is no interaction between the Platinum Capsules and Cimetidine? thanks for your reply.
Hi Darren, I think you are doing the right thing by increasing the dose gradually. Resveratrol is OK in low doses up to 50 mg, but at higher doses is an inhibitor of CYP1B1 and hinders the metabolism of the other salvestrols so its best to leave it out. Cimetidine is safe to take with salvestrols and does not inhibit their action.
Resveratrol is the first salvestrol discovered. It is metabolized by CYP1B1 to piceatannol, a known anti-cancer toxin. (G.A. Potter & M.D. Burke, Journal of Orthomolecular Medicine, Vol. 21, No. 1, 2006) Please explain how this is an inhibitor of CYP1B1.
You are correct, Resveratrol was the first salvestrol to be discovered and is metabolised to piceatannol which is toxic to cancer cells. The CYP1B1 has high velocity and low capacity, which means it metabolises low concentrations very efficiently but slows down as the concentration increases. At high concentrations the enzyme becomes clogged up and stops working so at high concentrations resveratrol starts acting as an inhibitor of CYP1B1. The optimum dose of resveratrol is calculated as 50mg, and doses above 100 mg doses cause inhibition so it is pointless taking higher doses than this. High concentrations of resveratrol not only inhibits its own metabolism, it also inhbits the activation of other salvestrols.
Hi and thanks for answering all of my questions, just one more, is it ok to take these Salvestrol tablets with Trans-Pterostilbene?
Trans Pterostilbene is OK in low doses of up to 50 mg, but above this level it is an inhibitor of CYP1B1 so it is best avoided when taking salvestrols.
Thanks for the information I am giving one of my clients a vitamin mix with .5mg of Trans Pterostilbene in it so I will keep him on it for now and see how it goes seeing its only a small dose. My client has been building up the dose of Salvestrols and is now on 1 tablet 3 times per day with meals.
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