Votrient Salvestrol Combo

Votrient (Pazopanib) is new anticancer drug licensed for treating soft tissue sarcomas. This works as a tyrosine kinase inhibitor to block the VEGF and PDGF mediated signalling pathways. Salvestrols also act as natural tyrosine kinase inhibitors so will potentiate the action of Votrient and also help to overcome drug resistance. Taking Salvestrols and Votrient make a powerful combination in the fight against cancer.

Can Zytiga be Taken at a Lower Dose ?

Take Two of These…and a Sandwich

Posted at 8:27 am CT on April 18, 2012

By John Easton
“Take medication on an empty stomach.” Patients dread seeing this warning on their pill bottles, knowing that it often means skipped meals and hungry rumbles in the hours before and after taking their medicine. The rationale for the empty stomach is to avoid the unpredictable effects of food on drug metabolism — depending on what you’ve eaten, different amounts of the medication can be absorbed into the bloodstream. But a new clinical trial at the University of Chicago Medicine is testing whether just the right mixture of food and drug could be more convenient for patients while saving a whole lot of money.

Abiraterone (trade named Zytiga), is a drug prescribed to men with castration-resistant prostate cancer. It also is more sensitive to food’s effects than any other marketed drug that is labeled to be taken on an empty stomach. Five times as much of the drug is taken up with a low-fat meal as on an empty stomach, and up to 10 times as much with a high-fat meal. Yet patients are told not to eat for two hours before and for one hour after taking their pills. As a result, taking Zytiga as directed means the amount of the drug absorbed by the body to fight cancer is decreased by 80 to 90 percent.

“This clinical trial is designed to assess the risks and benefits of taking this effective but costly drug with food,” said Russell Szmulewitz, assistant professor of medicine at the University of Chicago Medicine and director of the study. “Taking one pill with a meal, rather than four pills on a empty stomach, is much more convenient for patients, so it may improve compliance. It would also reduce the cost.”

The savings to patients and their insurance companies from taking lower doses of the drug would be significant, since the drug costs $5,000 a month.
“By taking one-fourth of the dose with a low-fat breakfast,” Szmulewitz said, “patients may be able to get the full medical benefit and save about $3,750 per month.”
The convenience would also appeal to patients. Many dislike having to fast for hours before and after taking their medication, which can upset an empty stomach. Since patients with advanced prostate cancer tend to be older, most take multiple medications for additional health issues, fitting each medication into a complicated daily routine. Many patients who take Zytiga wake up during the night, for example, to take the medicine, then go back to sleep, allowing them to eat soon after they wake up.

In the clinical trial, one-half of the study participants will take the standard 1,000 mg dose of Zytiga — four pills each morning while fasting. The other half will take one 250 mg pill each morning with a low-fat breakfast. All trial participants also will take prednisone, a steroid that helps prevent common side effects of Zytiga such as high blood pressure, low potassium levels and fluid accumulation.

Patients who are already taking Zytiga for prostate cancer should not “conduct such experiments on their own,” cautions co-investigator Mark Ratain, the Leon O. Jacobson professor of medicine and director of the Center for Personalized Therapeutics at the University of Chicago Medicine. The drug has not been carefully studied when taken with food. Careful monitoring of drug levels in the blood and its ability to stop or slow the growth of the cancer are central to the study.

“We do not yet know how well the drug will be absorbed or how it will impact the patient and his disease when delivered in this way,” Ratain said. “We know only what happens when it is taken on an empty stomach. In that setting, most of it gets flushed away at considerable expense.”

The Salvestrol Discovery Team

Picture from 2005 of the Cancer Drug Discovery Group, the team that discovered salvestrols. These are from left bottom row:

Professor Gerry Potter (Team Leader)
Dr Rebecca Bennet (mesothelioma expression of CYP1B1)
Dr Paul Butler (CYP1B1 expressing human tumour cell lines)
Dr Corrine Burnes (Phytochemistry)
Dr Ellen Gao (Prodrug synthesis)

Back Row:

Dr Asma Patel (Prodrug formulation)
Dr Saba Lodhi (Prodrug synthesis)
Dr Ketan Ruperalia (Drug design and synthesis)
Dr Randolf Arroo (Team Leader in Phytochemistry)
Dr Vassilios Androutsopoulos (Salvestrol biochemistry)
Dr Somchaiya Surichan (Salvestrol metabolism and biochemistry)

Discovering Salvestrols

Professor Gerry Potter discovering the salvestrol metabolic pathways mediated by CYP1B1. The structure drawn is of the chalcone series of salvestrols, in this case salvestrol C30 being bioactivated by CYP1B1 to the antimitotic metabolite salvestrol C40.

Incurable Mesothelioma Responds to Salvestrols

A diagnosis of mesothelioma (asbestos induced lung cancer) is usually followed by a fairly swift death sentence. There is currently no effective conventional treatment and most doctors give patients a life expectancy of no more than six to 12 months after a tumour develops.

But Alan Stafford, 63, is living proof that however bleak the outlook, you should not accept the prognosis lying down. He has confounded NHS doctors and oncology specialists by proving there is an alternative path – by taking salvestrols, herbal medicine, and following an organic diet.

Alan first developed symptoms of the cancerous disease back in August 2008, but was so determined to live long enough to celebrate his ruby wedding and wife Jenny’s 60th birthday in January 2010, he refused to give up hope.

Speaking from his bungalow in Great Sankey, Warrington, he says: “You can either sit down and die, or you can do something about it. You can’t just give up. It’s so easy, believe me, to give up, especially when you have just had chemotherapy, because it does make you ill. I just decided there must be something else I can try.”

Mesothelioma is a cancer caused by asbestos. Frighteningly it takes just a few asbestos fibres to lodge in the lung’s lining, perhaps many decades before, to wreak havoc today.

As an apprentice joiner more than 40 years ago, Alan recalls regularly having to work with materials containing asbestos. He believes he may also have come into contact with it in his later career as a self-employed heavy goods vehicle fitter. Whenever his fate was sealed, exposure to the toxic material has now turned his world upside down.

He first noticed a problem with his health in August 2008. Exhaustion, coupled with crushing chest pains in the middle of the night, resulted in him being rushed into Warrington Hospital accident and emergency with a suspected heart attack.

Various tests followed, but it took until December later that year for doctors to diagnose a cancer tumour on his left lung. In fact at first they thought it was so inconsequential they allowed him to fly off on a pre-booked break to Benidorm - his first foreign trip for ten years.

But back in Britain a week later, the holiday really was over. He was admitted to Broad Green Hospital in Liverpool for a biopsy just before Christmas and then finally heard the devastating news on December 30th, his 62nd birthday.

“We were told it was mesothelioma, which of course we had never even heard of. We didn’t know what it was.” he says.

“I just said, thank goodness it’s not lung cancer,” Jenny recalls wryly.

Very quickly the full reality of the situation hit home. “They said it was a terminal illness,” Alan adds. “The family were devastated when we first told them. My youngest son, Andy, took it really badly.”

Alan was sent for two sessions of chemotherapy at the specialist Clatterbridge cancer hospital on the Wirral, but his oncologist acknowledged the side effects were so severe, the treatment seemed to be doing him more harm than good.

Ultimately he ended up with fluid on his lung. Doctors arranged for a chest drain which removed four and a half litres of fluid from his body, but the drain unfortunately also burst the tumour and sucked some of the cancer cells through the chest wall and allowed them to lodge on the outside of his left shoulder.

Jenny teasingly acknowledges now: “You looked like the hunchback of Notre Dame” – a comment that would have been far too insensitive a year ago.

For him this was the low point. He had a rapidly expanding tumour the size of a rugby ball on his back, which was so large and hard he couldn’t sit back properly.

“It wasn’t very comfortable but it was more the psychological effect. You really were aware of your condition.” Alan remembers. “Even wearing loose-fitting

clothing you could see it. It made you feel worse. It brought it to your mind all the time.”

It was at this stage, he and Jenny reluctantly came to the conclusion conventional cancer treatment had no more to offer and decided to explore alternative medicine.

In February 2009 they took matters into their own hands and went for a consultation with Cheshire medical herbalist, Amanda Cutbill. As well as a herbal medicine degree, she is also a trained Salvestrol Therapist and has received specialist training at Bristol’s renowned Penny Brohn complementary cancer care centre.

Alan was bowled over with the personal attention. “The minute we came away from her, we felt as though something was going to be done. She was absolutely brilliant. Honestly I can’t praise Amanda enough. She inspired us.”

Amanda prescribed a range of herbal treatments to build up his immune system and improve his breathing, pulse and liver function. She also recommended a long-term course of Salvestrols, which contain highly concentrated extracts of fruits such as tangerine, strawberry, blackberry and blueberry. And to get the maximum benefit from this medicine, she advised him to follow a completely organic diet. Alan also has a mistletoe injection three times a week to boost his immune system’s ability to fight cancer cells.

Jenny changed her shopping habits immediately and now only buys organic products, even down to organic salt and pepper. She has also started cultivating her own vegetable plot in the back garden. And Alan increased his intake of fruit, vegetables and fish and cut down on red meat and dairy products.

Amanda recalls: “The results were dramatic. Within three months Alan’s tumour was receding. He was less breathless, had more energy, a healthy appetite and his pulse rate had come down to normal.”

In October 2009, Alan’s oncologist was so astounded by the results of a scan, he sent him back for another one, just to make sure.

Alan recalls: “He said he thought he was looking at someone else’s scan. He was amazed. He said – mesothelioma doesn’t act like that. And told me to keep on doing what I was doing – it was obviously working.”

Alan now feels better than at any time in the last 20 months. He used to be exhausted by a few short steps, now he is walking up hills and embarking on DIY projects for his two sons.

“I am convinced that the salvestrols I am taking are what is keeping me going,” he says.

On Sunday 17th January, Alan and Jenny Stafford renewed their wedding vows before family and friends in an emotional ceremony they thought he would never live to see.

Jenny recalls: “It was wonderful the fact that Alan was still able to walk down the aisle. It was just very emotional.”

Now, the couple treat every new day as a blessing. Alan continues to amaze NHS doctors with his miraculous improvement. The tumour is vastly reduced and the cancer no longer visible from outside his body.

“You have not got to let it ruin your life,” says Alan. “You have got to keep going. You have got to stay positive.”

His next goal is to attend the wedding of his youngest son, Andy, on June 12th – and perhaps even plan another holiday. And he certainly intends to stick to his organic diet and keep taking the salvestrols and herbal medicine.

Salvestrol Platinum 2000 UK and Worldwide Product

Authentic Salvestrol Platinum 2000 available in the UK and the rest of the world.

Salvestrol Platinum 2000 is the highest strength salvestrol supplement available and is the best supplement for cancer therapy. It contains very high levels of 4 salvestrols formulated together for optimum anticancer activity.

90 capsules gives a dose of 3 capsules (6000 points) daily for 1 months supply.

Manufactured by Salvestrol Natural Products

Distributed by 1880 Life

Available from

http://www.practitionerchoice.co.uk/

and

http://www.naturopharma.com/

Note: Product from the UK cannot be sent to countries that have a local distributor, i.e.
Canada, USA, NZ, Australia, South Africa, Denmark, Holland, Belgium, Spain

The above countries have a local distributor who will supply direct.

Salvestrol Platinum 1000 Capsules

Authentic Salvestrol Platinum 1000 Capsules available in the USA and Canada from
http://www.salvestrol.ca/
 and
http://www.fosterhealth.ca/

This contains 75 capsules of 1000 point salvestrol platinum capsules.

Salvestrol Platinum 1000 is the highest strength supplement available in the USA and Canada. This product is 10 times the strength of regular salvestrol vegetarian capsules. Salvestrols Platinum 1000 has been specially formulated for cancer therapy taken at a dose of 6 capsules daily. It contains 4 salvestrols working together to give a product with powerful anticancer activity.

Salvestrol Platinum 2000 in Europe by Vitals

Authentic Salvestrol Platinum 2000 available in Europe distributed by Vitals of Holland

Salvestrol Platinum 2000 is the highest strength salvestrol supplement available and is the best supplement  for cancer therapy. It is 20 times the strength of standard salvestrol vegetarian capsules and 6 times stronger than Salvestrol Shield (Fruit Force).

This product contains 4 different salvestrols formulated together for optimum anticancer activity.

Long Term Cancer Survivors Recommend Salvestrol Platinum

10 Year Survivor of Prostate Cancer Recommends Salvestrol Platinum.

In early 2002 I was diagnosed with prostate cancer after a biopsy. It was moderately aggressive (Gleason = 6) and involved both lobes. When the PSA rise got to be alarming I decided to try other options, since the cancer had already metastasized to other areas of my body. I was told that the doctors could offer no cure and that at the rate the PSA was doubling I would likely live less than 5 years .  In 2004, I started taking Salvestrol Platinum daily after hearing about it from a friend who had heard Professor Gerry Potter speak at a lecture in Penticton, BC Canada.  When I next went to the Cancer Clinic I had had another PSA test. Interestingly, it seemed to indicate a possible slowing of the tumour growth. When I returned home from the Cancer Clinic I used an equation to find the doubling time and I was able to determine that the PSA had previously doubled every 4 months. This is very bad news because a short doubling time indicates fast tumour growth. However, during the first two months of taking Salvestrol the doubling time lengthened to 20 months. During the next three months the doubling time lengthened again to 40 months (which is very good). This means that the tumour growth rate had slowed to a crawl from its very rapid growth only 5 months earlier. Based on these results, I calculated I will die of other causes before the cancer is a concern. I have been very conservative in my dosages. One capsule of Salvestrol Platinum per day was used during the first two months and then increased to two capsules per day for the last three months.

When I first saw my urologist after taking the salvestrol supplements he declared that the PSA result must be a lab error. The next time I saw him, with an even better result, he could see that this was not a lab error and he wanted to know what I was doing. He asked for information about Salvestrol and said that he was going to investigate it. He said that I seemed to be on the cutting edge of current research.

Based on my experience and the information that I have gathered, I recommend Salvestrol Therapy to anyone that has cancer of any kind or is at risk of cancer. I am writing this for people to read because I believe that a great deal of unnecessary suffering can be avoided by using Salvestrol as a preventative (low dosage) or a curative (higher dosage) for all types of cancer. It is safe to take even at high doses and can be used alone or in conjunction with other treatments recommended by doctors. If the situation is not an emergency or the doctors have given up, then giving Salvestrol a trial for three months seems like a good plan.

Ken,

Canada

5 Year Survivor of Breast Cancer Recommends Salvestrol Platinum.

I would like to say that I swear by a supplement called Salvestrol Platinum. I've been taking it since my diagnosis of stage 3 breast cancer 5 years ago in 2007. Like all natural things, there's no double-blind trials offering scientific 'proof' but the theory behind it makes sense to me so I'm going to keep taking it as long as I live, as it is meant to be highly 'anti-cancer' and as a bonus it seems to do wonders for my skin. After diagnosis, I stopped taking lymecyclene and thought I would just have to put up with nasty spots. But as soon as I started taking Salvestrols the improvement in my skin was astonishing and fast. They are not expensive at about £1 per day. I'm lucky that I can afford it - I buy supplements and good food rather than spend my money on meals out, etc. That's my suggestion. Good luck with whatever you decide to try.

It's not my profession or anything to do with making money. This is material I researched myself upon diagnosis, because I wanted to try and help myself rather than rely just on what conventional medicine offers/insists on, and I think this advice will help others who have breast cancer. The main evidence I have is that I have recovered from cancer and feel much better than before I was diagnosed - and I mean both physically and mentally better. When I stray from my routine of diet and supplements, it shows in my skin very quickly - so I have come to believe my skin is a 'barometer' of my internal health.

Salvestrols are based on the idea that the anti-fungal, anti-bacterial and anti-cancer properties of fruits and veg reside in the skin of the fruit and have been largely destroyed by food processing and the last 6 decades of industrial farming. So even if you eat lots of fruit and veg, they may no longer provide you with the healthy nutrients they did when agriculture was more natural, when the plants had to use their own immune systems to fight disease - rather than pesticides and fungicides doing this for them.

So Salvestrols are made from older varieties of fruits and veg, ones that have not been industrially farmed, and therefore retain their own immune defenses which are beneficial when eaten. In terms of cancer, salvestrols are said to be able to break through the protein coating of cancer cells, and trigger an enzyme inside the cancer cell to make it die.

That's the theory.
Best wishes, B

Salvestrol Q40 Induces Cancer Cell Death by Apoptosis

A new study has described the molecular mechanism of action by which the flavonoid salvestrol Q40 induces breast cancer cell death. Salvestrol Q40 has been shown to exert anticancer activity in various types of human cancer cells. In this study, salvestrol Q40 was found to cause a decrease in breast cancer cell viability in a dose-dependent and time-dependent manner. Cell cycle measurements and staining demonstrated that salvestrol Q40 induced programmed cell death (apoptosis).

In addition, salvestrol Q40 was shown to induce activation of extracellular signal regulated kinase (ERK) and p38. This was confimed by the fact that pharmacological inhibition or knockdown of ERK and p38 was found to protect against salvestrol Q40-induced cell death. Further testing using immunocytochemistry demonstrated that salvestrol Q40 triggers apoptosis-inducing factor (AIF) nuclear translocation, which in turn was mediated by activation of ERK and p38. This result was again supported by the fact that transfection of vector expressing microRNA of AIF prevented the salvestrol Q40-induced cell death. The authors conclude that salvestrol Q40 induces caspase-dependent apoptosis involving AIF nuclear translocation mediated by activation of ERK and p38 in breast cancer cells.

Comments regarding the study

Flavonoids are plant pigments found primarily in fruits and vegetables. Like salvestrol T30, salvestrol Q40 is a flavone, a subclass of flavonoids. These two flavones are often found together in the same foods. Parsley and celery are the most abundant food sources of salvestrol Q40; it is also found in bell peppers and hot peppers, carrots, artichokes, olives and olive oil, as well as spices such as mint, rosemary, sage and thyme. Numerous studies have reported that flavones induce programmed cell death in various types of cancer cells, including breast cancer. Salvestrol Q40 has also been shown to increase the anti-cancer effects of the chemotherapy drugs Adriamycin (doxorubicin) and Taxol (paclitaxel). Italian population studies have reported that high dietary intake of flavones is associated with lower risk of breast cancer.

Salvestrol Q40 Inhibits TNF Survival of Cancer Cells

Tumor necrosis factor-alpha (TNFalpha) activates both cell death and cell survival pathways, which render most cancer cells resistant to its cytotoxicity. In this study, we found that pretreatment with salvestrol Q40, a plant flavonoid, greatly sensitized TNFalpha-induced apoptotic cell death in a number of human cancer cell lines; including colorectal cancer COLO205, HCT116 cells and cervical cancer HeLa cells. In the search of the molecular mechanisms responsible for the sensitization effect of salvestrol Q40, we discovered that salvestrol Q40 inhibited TNFalpha-induced activation of nuclear transcription factor-kappa B (NF-kappaB), the main survival factor in TNFalpha signaling. As a result, salvestrol Q40 suppressed the expression of NF-kappaB-targeted antiapoptotic genes, including A20 and cellular inhibitor of apoptosis protein-1 (c-IAP1). The role of A20 and c-IAP1 was further confirmed by ectopic expression of these two genes, which significantly protected cell death induced by salvestrol Q40 followed by TNFalpha. In addition, inhibition of NF-kappaB by salvestrol Q40 led to augmentation and prolongation of c-Jun N-terminal kinase (JNK) activation induced by TNFalpha. Suppression of JNK activation, either by a synthetic JNK inhibitor (SP600125) or by overexpression of the dominant negative forms of JNK kinase 1 (JNKK1) and JNK kinase 2 (JNKK2), conferred significant protection against apoptotic cell death induced by salvestrol Q40 and TNFalpha, suggesting that NF-kappaB and JNK are closely associated with the sensitization effect of salvestrol Q40. Data from this study reveal a novel function of salvestrol Q40 and enhance the value of salvestrol Q40 as an anticancer agent.

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an important member of the TNF superfamily with great potential in cancer therapy. Salvestrol Q40 is a dietary flavonoid commonly found in some medicinal plants. Here we found that pretreatment with a noncytotoxic concentration of salvestrol Q40 significantly sensitized TRAIL-induced apoptosis in both TRAIL-sensitive (HeLa) and TRAIL-resistant cancer cells (CNE1, HT29, and HepG2). Such sensitization is achieved through enhanced caspase-8 activation and caspase-3 maturation. Further, the protein level of X-linked inhibitor of apoptosis protein (XIAP) was markedly reduced in cells treated with salvestrol Q40 and TRAIL, and ectopic expression of XIAP protected against cell death induced by salvestrol Q40 and TRAIL, showing that salvestrol Q40 sensitizes TRAIL-induced apoptosis through down-regulation of XIAP. In search of the molecular mechanism responsible for XIAP down-regulation, we found that salvestrol Q40 and TRAIL promoted XIAP ubiquitination and proteasomal degradation. Next, we showed that protein kinase C (PKC) activation prevented cell death induced by salvestrol Q40 and TRAIL via suppression of XIAP down-regulation. Moreover, salvestrol Q40 inhibited PKC activity, and bisindolylmaleimide I, a general PKC inhibitor, simulated salvestrol Q40 in sensitizing TRAIL-induced apoptosis. Taken together, these results present a novel anticancer effect of salvestrol Q40 and support its potential application in cancer therapy. In addition, our data reveal a new function of PKC in cell death: PKC activation stabilizes XIAP and thus suppresses TRAIL-induced apoptosis.

Much of the current research in cancer therapeutics is aimed at developing drugs to target key molecules for combating tumor cell growth, metastasis, proliferation, or changes in the associated stromal microenvironment. Studies on a wide spectrum of plant secondary metabolites extractable as natural products from fruits, vegetables, teas, spices, and traditional medicinal herbs show that these plant natural products can act as potent anti-inflammatory, antioxidant or anticancer agents. The recent advances in genomics and metabolomics have enabled biologists to better investigate the potential use of immunomodulatory natural products for treatment or control of various cancerous diseases. The cancer preventive or protective activities of the various immunomodulatory natural products lie in their effects on cellular defenses including detoxifying and antioxidant enzyme systems, and the induction of anti-inflammatory and antitumor or antimetastasis responses, often by targeting specific key transcription factors like nuclear factor kappa B (NF-kappaB), activator protein (AP-1), signal transducers and activators of transcription (STAT) and others. This review presents recent findings and hypotheses on the molecular mechanisms through which various inflammatory activities are linked to tumorigenic processes and the specific immunomodulatory natural products that may suppress inflammation and the associated tumor progression and metastasis both IN VITRO and IN VIVO. In addition to tumor cells PER SE, the various associated roles of myeloid-derived suppressor cells, stromal fibroblasts, myofibroblasts, and inflammatory immune cells, and the possible effects of phytomedicines on these cells in the tumor microenvironment.

Salvestrol Q40 Inhibits PI3K / akt Signalling Pathway

Salvestrol Q40 inhibits the PI3K / akt signalling pathway and induces cell death by apoptosis due to elevated Bax to Bcl-2 ratio. Salvestrol Q40 is a flavonoid that exists in many types of plants including fruits, vegetables, and medicinal herbs. Plants rich in salvestrol Q40 have been used in Chinese traditional medicine for treating various diseases such as hypertension, inflammatory disorders, and cancer. Having multiple biological effects such as anti-inflammation, anti-allergy and anticancer, salvestrol Q40 functions as a substrate for CYP activase enzymes. The biological effects of salvestrol Q40 could be functionally related to each other. For instance, the anti-inflammatory activity may be linked to its anticancer property. Salvestrol Q40's anticancer property is associated with the induction of apoptosis, and inhibition of cell proliferation, metastasis and angiogenesis. Furthermore, salvestrol Q40 sensitizes cancer cells to therapeutic-induced cytotoxicity through suppressing cell survival pathways such as phosphatidylinositol 3'-kinase (PI3K)/Akt, nuclear factor kappa B (NF-kappaB), and X-linked inhibitor of apoptosis protein (XIAP), and stimulating apoptosis pathways including those that induce the tumor suppressor p53. These observations suggest that salvestrol Q40 could be an anticancer agent for various cancers. Furthermore, recent epidemiological studies have attributed a cancer prevention property to salvestrol Q40. Here is summarized the progress of recent research on salvestrol Q40, with a particular focus on its anticancer role and molecular mechanisms underlying this property of salvestrol Q40.

Epidemiological evidence suggests that flavonoids may play an important role in the decreased risk of chronic diseases associated with a diet rich in plant-derived foods. Flavonoids are also common constituents of plants used in traditional medicine to treat a wide range of diseases. The purpose of this article is to summarize the distribution and biological activities of one of the most important flavonoids: salvestrol Q40. This flavonoid and its glycosides are widely distributed in the plant kingdom; they are present in many plant families and have been identified in Bryophyta, Pteridophyta, Pinophyta and Magnoliophyta. Dietary sources of salvestrol Q40 include, for instance, carrots, peppers, celery, olive oil, peppermint, thyme, rosemary and oregano. Preclinical studies have shown that this flavone possesses a variety of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial and anticancer activities. The ability of salvestrol Q40 to inhibit angiogenesis, to induce apoptosis, to prevent carcinogenesis in animal models, to reduce tumor growth in vivo and to sensitize tumor cells to the cytotoxic effects of some anticancer drugs suggests that this flavonoid has cancer chemopreventive and chemotherapeutic potential. Modulation of ROS levels, inhibition of topoisomerases I and II, reduction of NF-kappaB and AP-1 activity, stabilization of p53, and inhibition of PI3K, STAT3, IGF1R and HER2 are possible mechanisms involved in the biological activities of salvestrol Q40.