Votrient Salvestrol Combo

Votrient (Pazopanib) is new anticancer drug licensed for treating soft tissue sarcomas. This works as a tyrosine kinase inhibitor to block the VEGF and PDGF mediated signalling pathways. Salvestrols also act as natural tyrosine kinase inhibitors so will potentiate the action of Votrient and also help to overcome drug resistance. Taking Salvestrols and Votrient make a powerful combination in the fight against cancer.

Can Zytiga be Taken at a Lower Dose ?

Take Two of These…and a Sandwich

Posted at 8:27 am CT on April 18, 2012

By John Easton
“Take medication on an empty stomach.” Patients dread seeing this warning on their pill bottles, knowing that it often means skipped meals and hungry rumbles in the hours before and after taking their medicine. The rationale for the empty stomach is to avoid the unpredictable effects of food on drug metabolism — depending on what you’ve eaten, different amounts of the medication can be absorbed into the bloodstream. But a new clinical trial at the University of Chicago Medicine is testing whether just the right mixture of food and drug could be more convenient for patients while saving a whole lot of money.

Abiraterone (trade named Zytiga), is a drug prescribed to men with castration-resistant prostate cancer. It also is more sensitive to food’s effects than any other marketed drug that is labeled to be taken on an empty stomach. Five times as much of the drug is taken up with a low-fat meal as on an empty stomach, and up to 10 times as much with a high-fat meal. Yet patients are told not to eat for two hours before and for one hour after taking their pills. As a result, taking Zytiga as directed means the amount of the drug absorbed by the body to fight cancer is decreased by 80 to 90 percent.

“This clinical trial is designed to assess the risks and benefits of taking this effective but costly drug with food,” said Russell Szmulewitz, assistant professor of medicine at the University of Chicago Medicine and director of the study. “Taking one pill with a meal, rather than four pills on a empty stomach, is much more convenient for patients, so it may improve compliance. It would also reduce the cost.”

The savings to patients and their insurance companies from taking lower doses of the drug would be significant, since the drug costs $5,000 a month.
“By taking one-fourth of the dose with a low-fat breakfast,” Szmulewitz said, “patients may be able to get the full medical benefit and save about $3,750 per month.”
The convenience would also appeal to patients. Many dislike having to fast for hours before and after taking their medication, which can upset an empty stomach. Since patients with advanced prostate cancer tend to be older, most take multiple medications for additional health issues, fitting each medication into a complicated daily routine. Many patients who take Zytiga wake up during the night, for example, to take the medicine, then go back to sleep, allowing them to eat soon after they wake up.

In the clinical trial, one-half of the study participants will take the standard 1,000 mg dose of Zytiga — four pills each morning while fasting. The other half will take one 250 mg pill each morning with a low-fat breakfast. All trial participants also will take prednisone, a steroid that helps prevent common side effects of Zytiga such as high blood pressure, low potassium levels and fluid accumulation.

Patients who are already taking Zytiga for prostate cancer should not “conduct such experiments on their own,” cautions co-investigator Mark Ratain, the Leon O. Jacobson professor of medicine and director of the Center for Personalized Therapeutics at the University of Chicago Medicine. The drug has not been carefully studied when taken with food. Careful monitoring of drug levels in the blood and its ability to stop or slow the growth of the cancer are central to the study.

“We do not yet know how well the drug will be absorbed or how it will impact the patient and his disease when delivered in this way,” Ratain said. “We know only what happens when it is taken on an empty stomach. In that setting, most of it gets flushed away at considerable expense.”

The Salvestrol Discovery Team

Picture from 2005 of the Cancer Drug Discovery Group, the team that discovered salvestrols. These are from left bottom row:

Professor Gerry Potter (Team Leader)
Dr Rebecca Bennet (mesothelioma expression of CYP1B1)
Dr Paul Butler (CYP1B1 expressing human tumour cell lines)
Dr Corrine Burnes (Phytochemistry)
Dr Ellen Gao (Prodrug synthesis)

Back Row:

Dr Asma Patel (Prodrug formulation)
Dr Saba Lodhi (Prodrug synthesis)
Dr Ketan Ruperalia (Drug design and synthesis)
Dr Randolf Arroo (Team Leader in Phytochemistry)
Dr Vassilios Androutsopoulos (Salvestrol biochemistry)
Dr Somchaiya Surichan (Salvestrol metabolism and biochemistry)

Discovering Salvestrols

Professor Gerry Potter discovering the salvestrol metabolic pathways mediated by CYP1B1. The structure drawn is of the chalcone series of salvestrols, in this case salvestrol C30 being bioactivated by CYP1B1 to the antimitotic metabolite salvestrol C40.

Incurable Mesothelioma Responds to Salvestrols

A diagnosis of mesothelioma (asbestos induced lung cancer) is usually followed by a fairly swift death sentence. There is currently no effective conventional treatment and most doctors give patients a life expectancy of no more than six to 12 months after a tumour develops.

But Alan Stafford, 63, is living proof that however bleak the outlook, you should not accept the prognosis lying down. He has confounded NHS doctors and oncology specialists by proving there is an alternative path – by taking salvestrols, herbal medicine, and following an organic diet.

Alan first developed symptoms of the cancerous disease back in August 2008, but was so determined to live long enough to celebrate his ruby wedding and wife Jenny’s 60th birthday in January 2010, he refused to give up hope.

Speaking from his bungalow in Great Sankey, Warrington, he says: “You can either sit down and die, or you can do something about it. You can’t just give up. It’s so easy, believe me, to give up, especially when you have just had chemotherapy, because it does make you ill. I just decided there must be something else I can try.”

Mesothelioma is a cancer caused by asbestos. Frighteningly it takes just a few asbestos fibres to lodge in the lung’s lining, perhaps many decades before, to wreak havoc today.

As an apprentice joiner more than 40 years ago, Alan recalls regularly having to work with materials containing asbestos. He believes he may also have come into contact with it in his later career as a self-employed heavy goods vehicle fitter. Whenever his fate was sealed, exposure to the toxic material has now turned his world upside down.

He first noticed a problem with his health in August 2008. Exhaustion, coupled with crushing chest pains in the middle of the night, resulted in him being rushed into Warrington Hospital accident and emergency with a suspected heart attack.

Various tests followed, but it took until December later that year for doctors to diagnose a cancer tumour on his left lung. In fact at first they thought it was so inconsequential they allowed him to fly off on a pre-booked break to Benidorm - his first foreign trip for ten years.

But back in Britain a week later, the holiday really was over. He was admitted to Broad Green Hospital in Liverpool for a biopsy just before Christmas and then finally heard the devastating news on December 30th, his 62nd birthday.

“We were told it was mesothelioma, which of course we had never even heard of. We didn’t know what it was.” he says.

“I just said, thank goodness it’s not lung cancer,” Jenny recalls wryly.

Very quickly the full reality of the situation hit home. “They said it was a terminal illness,” Alan adds. “The family were devastated when we first told them. My youngest son, Andy, took it really badly.”

Alan was sent for two sessions of chemotherapy at the specialist Clatterbridge cancer hospital on the Wirral, but his oncologist acknowledged the side effects were so severe, the treatment seemed to be doing him more harm than good.

Ultimately he ended up with fluid on his lung. Doctors arranged for a chest drain which removed four and a half litres of fluid from his body, but the drain unfortunately also burst the tumour and sucked some of the cancer cells through the chest wall and allowed them to lodge on the outside of his left shoulder.

Jenny teasingly acknowledges now: “You looked like the hunchback of Notre Dame” – a comment that would have been far too insensitive a year ago.

For him this was the low point. He had a rapidly expanding tumour the size of a rugby ball on his back, which was so large and hard he couldn’t sit back properly.

“It wasn’t very comfortable but it was more the psychological effect. You really were aware of your condition.” Alan remembers. “Even wearing loose-fitting

clothing you could see it. It made you feel worse. It brought it to your mind all the time.”

It was at this stage, he and Jenny reluctantly came to the conclusion conventional cancer treatment had no more to offer and decided to explore alternative medicine.

In February 2009 they took matters into their own hands and went for a consultation with Cheshire medical herbalist, Amanda Cutbill. As well as a herbal medicine degree, she is also a trained Salvestrol Therapist and has received specialist training at Bristol’s renowned Penny Brohn complementary cancer care centre.

Alan was bowled over with the personal attention. “The minute we came away from her, we felt as though something was going to be done. She was absolutely brilliant. Honestly I can’t praise Amanda enough. She inspired us.”

Amanda prescribed a range of herbal treatments to build up his immune system and improve his breathing, pulse and liver function. She also recommended a long-term course of Salvestrols, which contain highly concentrated extracts of fruits such as tangerine, strawberry, blackberry and blueberry. And to get the maximum benefit from this medicine, she advised him to follow a completely organic diet. Alan also has a mistletoe injection three times a week to boost his immune system’s ability to fight cancer cells.

Jenny changed her shopping habits immediately and now only buys organic products, even down to organic salt and pepper. She has also started cultivating her own vegetable plot in the back garden. And Alan increased his intake of fruit, vegetables and fish and cut down on red meat and dairy products.

Amanda recalls: “The results were dramatic. Within three months Alan’s tumour was receding. He was less breathless, had more energy, a healthy appetite and his pulse rate had come down to normal.”

In October 2009, Alan’s oncologist was so astounded by the results of a scan, he sent him back for another one, just to make sure.

Alan recalls: “He said he thought he was looking at someone else’s scan. He was amazed. He said – mesothelioma doesn’t act like that. And told me to keep on doing what I was doing – it was obviously working.”

Alan now feels better than at any time in the last 20 months. He used to be exhausted by a few short steps, now he is walking up hills and embarking on DIY projects for his two sons.

“I am convinced that the salvestrols I am taking are what is keeping me going,” he says.

On Sunday 17th January, Alan and Jenny Stafford renewed their wedding vows before family and friends in an emotional ceremony they thought he would never live to see.

Jenny recalls: “It was wonderful the fact that Alan was still able to walk down the aisle. It was just very emotional.”

Now, the couple treat every new day as a blessing. Alan continues to amaze NHS doctors with his miraculous improvement. The tumour is vastly reduced and the cancer no longer visible from outside his body.

“You have not got to let it ruin your life,” says Alan. “You have got to keep going. You have got to stay positive.”

His next goal is to attend the wedding of his youngest son, Andy, on June 12th – and perhaps even plan another holiday. And he certainly intends to stick to his organic diet and keep taking the salvestrols and herbal medicine.

Salvestrol Platinum 2000 UK and Worldwide Product

Authentic Salvestrol Platinum 2000 available in the UK and the rest of the world.

Salvestrol Platinum 2000 is the highest strength salvestrol supplement available and is the best supplement for cancer therapy. It contains very high levels of 4 salvestrols formulated together for optimum anticancer activity.

90 capsules gives a dose of 3 capsules (6000 points) daily for 1 months supply.

Manufactured by Salvestrol Natural Products

Distributed by 1880 Life

Available from

http://www.practitionerchoice.co.uk/

and

http://www.naturopharma.com/

Note: Product from the UK cannot be sent to countries that have a local distributor, i.e.
Canada, USA, NZ, Australia, South Africa, Denmark, Holland, Belgium, Spain

The above countries have a local distributor who will supply direct.

Salvestrol Platinum 1000 Capsules

Authentic Salvestrol Platinum 1000 Capsules available in the USA and Canada from
http://www.salvestrol.ca/
 and
http://www.fosterhealth.ca/

This contains 75 capsules of 1000 point salvestrol platinum capsules.

Salvestrol Platinum 1000 is the highest strength supplement available in the USA and Canada. This product is 10 times the strength of regular salvestrol vegetarian capsules. Salvestrols Platinum 1000 has been specially formulated for cancer therapy taken at a dose of 6 capsules daily. It contains 4 salvestrols working together to give a product with powerful anticancer activity.