Sunday, 20 May 2012

Salvestrol Recipes - Artichoke & Broccoli

Artichokes and Broccoli are 2 of the top superfoods when it comes to salvestrol content.

Artichokes contain 5% dry weight of pure salvestrols and are the No1 food in this respect. The artichoke is one of the foods referred to by Hippocrates when he said "Let food be your medicine, and medicine be your food" so its medicinal properties have been known for centuries. Include artichokes as a pizza topping together with olives and capers. The artichoke is a large thistle head and belongs to the thistle family which includes other medicinal herbs that are rich in salvestrols such as burdock, milk thistle and blessed thistle. The thistles belong to an even larger plant family known as the compositae family which includes many common yellow flowered wild herbs such as dandelion and daisy. It also includes the sunflower and the jerusalem artichoke which has delicious edible roots that are naturally rich in salvestrols. Real Dandelion and Burdock root beer would make a real medicinal brew if it were only made with real dandelion and burdock roots. Burdock root forms part of the Essiac herbal mixture and is also present in the Hoxsey Remedy for cancer. So plants from the compositae family as a whole have had widespread historical use as medicinal herbs.

Broccoli is another cancer busting vegetable that can be used in juicing to get the maximum intake. When juicing a 1 kg portion will yield 100 salvestrol points. Broccoli are part of the cabbage family of cruciferous vegetables and all of this family have high salvestrol content. This family of vegetables includes cabbage broccoli savoy cabbage chinese leaf brussel sprouts and water cress.

5. ARTICHOKES IN DIPPING SAUCE

Rinse artichokes and cut 1 inch off the tops.
With scissors, trim off the thorny tips of the
remaining leaves. In a large saucepan, sauté
onion, garlic, mint and rosemary in oil. Add
lemon juice, vinegar, water and salt. Place
artichokes in seasoned broth; cover and
simmer until tender, about 40 minutes.
Allow to cool in the broth. To serve, place
each artichoke in a bowl with some of the
broth to use as a dipping sauce.

INGREDIENTS
4 medium artichokes
2 cloves garlic, minced
1/2 tsp. crumbled rosemary
2 Tbls. lemon juice
1/2 cup water
1 onion, chopped
2 Tbls. minced fresh mint
1/4 cup olive oil (stone ground)
1/2 cup cider vinegar
1/2 tsp. salt

6. BROCCOLI WITH GARLIC MAYONNAISE

Mix mayonnaise and garlic. Cover and
refrigerate about 2 hours. Cut broccoli
stalks lengthwise into thin spears. Place
streamer basket in 1/2-inch water in
saucepan or skillet (water should not touch
the bottom of basket). Place broccoli in
basket. Cover tightly and heat to boiling;
reduce heat. Steam until tender, about 15
minutes. Cover and refrigerate until chilled,
at least 2 hours. Sprinkle mayonnaise
mixture with paprika. Serve with broccoli.

INGREDIENTS
1/2 cup mayonnaise, or
1/2 cup salad dressing
2 medium garlic cloves,
crunched
1-1/2 lb. broccoli
paprika

Salvestrols Used to Prevent Cancer Recurrence

Breast Cancer Survivor Testimonial

Okay so here we go: Seven “Interesting” Facts you may not know about me……
  1. I’ve been a vegetarian for 25 years
  2. When I was 13 I saw an episode of the TV show MASH where they had a pet lamb. By the end of the show they had to eat it. I never ate meat again.
  3. I developed breast cancer 2 years ago aged 36. I’ve just finished my treatment which was 6 months of chemo & lapatinib (a clinical trial) followed by an operation to remove the tumor. Then 6 weeks of radiotherapy and then a year of Herceptin.
  4. I now feel better than ever and attribute my swift recovery to a combination of conventional treatment, healthy diet (during treatment I stopped eating dairy (cow) products and all sugars), reiki sessions and some alternative medicines such as Salvestrol, LDN and Melatonin. I swear by Salvestrol and LDN and I will continue to take these for the rest of my life.
  5. We used to own a restaurant where I designed the menus but I never went in the kitchen, except to make tea.
  6. None of my friends and family can believe that I now cook because from the age of 18 I lived on a diet that consisted of Marks & Spencer’s mashed potato and hummus, and I NEVER cooked!
  7. My ambition is to publish a vegetarian/vegan cookbook that will be a  vegetarian culinary journey around the world.

Saturday, 19 May 2012

Salvestrol Platinum Arrives in Australia & New Zealand

Salvestrol Platinum (2000 point) capsules are now available in Australia & New Zealand from

http://www.salvestrol.co.nz/

Friday, 18 May 2012

Salvestrol Enhancing Supplements

The majority of supplements are completely safe to take with salvestrols. In fact there is only one real exception which is Laetrile (B17) which inhibits the CYP1B1 enzyme and prevents the salvestrols from working. So the only supplement that interferes with Salvestrols is Laetrile (B17). This is an extract from apple and apricot seeds and contains cyanohydrins. These break down in the liver to generate cyanide. The cyanide generated inhibits the CYP1B1 enzyme so that it cannot function. So in the prescence of Laetrile salvestrols cannot work properly, and this supplement is to be avoided when using salvestrol therapy.
All other supplements are compatible with salvestrols and some may enhance their action.
Enhancing supplements are
Biotin
Magnesium
Niacin (Vitamin B3)
Vitamin C
Some other supplements also contain salvestrols such as Essiac Flor-Essence (100 points).
The testimonial on testicular cancer showed that salvestrols worked to shrink the testicular cancer without recourse to chemotherapy or surgery.
When tumours have a low level of CYP1B1 the expression can be increased by using an inducing agent. One such inducing agents is Salvestrol T55 which is now incorporated into the Salvestrol Platinum product to boost CYP1B1 levels. In this respect supplements containing the indoles I3C and DIM would also be useful since these agents can increase CYP1B1 expression levels. These can be obtained from brassica family vegetables and supplements containing indole 3 carbinol (I3C) and DIM are available.
Salvestrol Platinum contains 4 different salvestrols all working in harmony together to produce the optimum results. Each aids the action of the other and together they make a powerful product.

Vitamin C & Salvestrols

Could the use of Vit. C IV`S be interfering with the efficacy of Salvestrol Therapy in that that the purpose as explained by my MD if for the Vit. C to form a collagen over/around the pc cells to stop them from spreading. Maybe the collagen gets inthe way ? My MD told me that Vit. C does not do a good job of killing pc cells but rather stops them from spreading. My MD is not overly concerned with my PSA score. He is supportive of my using the urine test utilized by the N a v v a r o Clinic. This could account for your observations re slow and fast responders as there must be other products such as resveratol and modified citrus pectin that reduce the efficacy of Salvestrol ?? I look forward to your thoughts.
Heres the Reply:
Vitamin C does not interfere with salvestrol therapy. Indeed the two approaches are complimentary. The use of high dose vitamin C with salvestrols is being succesfully used in the Issels Clinic in California.
Many salvestrol supplements contain Vitamin C such as the salvestrol vegetarian capsules. Vitamin C is thought to help the activity of salvestrols and also acts as a preservative preventing the salvestrols from premature oxidation.

Doctors Recommend Salvestrols For Cancer

I have taken salvestrol daily for the past few years.  It is an important part of the alternative protocol my doctor recommends for his cancer patients.  Here is an interesting video explaining what salvestrols are and how they work to fight cancer.

Thursday, 17 May 2012

Salvestrols Beat Breast Cancer

Salvestrols work really well against breast cancer, probably due to the high expression of the salvestrol activase enzyme CYP1B1 in breast cancer cells. In practise there is a very high response rate when salvestrols are used to treat breast cancer. The typical response is cancer regression with tumours shrinking to half their size within 3 months of salvestrol supplementation at 3 capsules (6000 points) daily, and after 6 months are cancer free. In some cases ther is an even more rapid response within a month while other cases show that higher doses are needed. The highest dose needed to obtain a response is 6 capsules (12,000 points) daily.

There have been several cases reported recently to the salvestrol info team of responses at the dose of 12,000 points daily which seems to be the most effective dose so far used. In one case a lady had primary breast cancer that had spread to her brain and consequently she had lost her eyesight and was blind. Her recovery was truely miraculous and 1 month after taking the salvestrols she started to regain her sight and after 2 months the brain tumours had disappeared and she had regained her full sight again. Such feedback to the salvestrol info team is very encouraging and will give hope to many who are in deperate circumstances with cancer and nowhere else to turn for a safe and effective treatment.

Here is an example of a lady who had stage 3 breast cancer and recovered by taking salvestrols:

A 36-year-old woman was diagnosed with aggressive stage 3 breast cancer, following biopsies and blood tests. A 3-5 cm tumour was found under the right breast and a larger tumour was found in an underarm lymph node. The breast tumour looked the size of a golf ball on the image. She was told that her situation was really serious. After her first round of chemotherapy she learned about Salvestrols, and began taking one (2,000 point) Salvestrol Platinum capsule per day. Feeling ‘rock bottom’ at the time she skeptically wondered how on earth these capsules were going to help. Consequently she was very surprised to find that the pain associated with the tumours soon disappeared and the tumours began to shrink quickly. She began to feel that ‘she was going to be OK.’ This prompted her to learn more about Salvestrols and after learning more she switched to a completely organic diet. This simultaneously increased her intake of Salvestrols and their cofactors. Prior to her next chemotherapy session she was examined by her oncologist who remarked that she thought that the tumours were gone. Ultrasound and mammography were scheduled to assist the surgeons. To everyone’s surprise the radiologist could find no trace of the tumours through ultrasound and only a shadow was visible on the mammogram, so it was decided that surgery was unnecessary. She continues to take 1 capsule per day of Salvestrol Shield (350 point) as a preventative measure and has noticed her periods have resumed. Four months after refusing further chemotherapy her hair has grown back and she reported that she looked and felt wonderful.

Monday, 14 May 2012

New Book on Discovery of Salvestrols



A new book has been published by Dr Brian Schaefer detailing the background to the discovery of salvestrols and why they are important in the treatment of cancer.

http://www.salvestrolbook.com/

Salvestrols - Nature's Defence Against Cancer

Salvestrols are a new class of natural compounds that have a pharmacological definition rather than a chemical definition. They are defined by the action of the metabolites produced when they are metabolised by the CYP1B1 enzyme in cancer cells. Simply put, salvestrols are food-based compounds that are metabolised by CYP1B1 to produce metabolites that are anticancer agents. These anticancer agents suppress tumour growth by killing the cancer cells. Salvestrols provide an explanation of the link between diet and cancer and between fruit and vegetable consumption and lower cancer incidence.

Readers Comments:

I have just read brian schaefers book- "Salvestrols natures defense against cancer" and am in awe of the incredible work that has been done to get Salvestrols available as they are now, and of the research going into the testing to monitor the progress and efficacy of treatment. The book is superbly written in an easy to read format. I highly recommend it to any one with any cancer challenge or interest in a healthy cancer free life.

Sunday, 13 May 2012

Salvestrol Recipes - Asparagus & Carrots

 
INGREDIENTS
2 doz. fresh, thin asparagus
spears
1 cup butter
2 fresh cloves garlic
2 tsp. lemon juice
1 tbsp. parsley
grated lemon rind
parsley sprigs

ORGANIC CARROTS & MINT
Wash organic carrots, but do not peel. Place in
a large skillet. Add boiling water, to partly
cover, and the salt and simmer, covered,
for 10 minutes or until carrots are
tender. Drain carrots and save water to make a gravy.
Melt butter in a large
skillet. Add mint, and carrots.
Cook over low heat, turning carrots
frequently, until they are nicely glazed. Turn
into a serving dish. Garnish with mint sprigs,
if desired. Serves 8.
INGREDIENTS
24 small organic carrots (2 lb.)
boiling water
1 tsp. salt
2 Tbsp. butter or margarine
2 Tbsp. fresh mint leaves,
chopped


Asparagus is one of the top foods for salvestrol content. These are the sprouting spears of the asparagus plant and are naturally rich in salvestrols. Asparagus can be used as part of the Gerson Diet and has been shown to be effective against prostate cancer.
Organic carrots are a rich source of salvestrols and have over 10 times more than non-organic carrots. Herbs such as parsley and mint grow happily without any antifungal agents and are naturally rich in herbal salvestrols which are amongst the most potent known. Combining asparagus and parsley, and organic carrots and mint provides a fun way to obtain salvestrols with amazing flavours.

FRESH ASPARAGUS IN BUTTER SAUCE
Wash spears and snap off white ends,
Cut spears into bias-sliced chunks about
2" long. In a wok or frying pan, melt
butter. Press garlic through a press and
add with lemon juice and parsley flakes
to butter. Heat over medium-high heat.
Add asparagus and stir constantly until
vegetables are crisp-tender. Remove
asparagus to warm serving dish. Add lemon
rind to butter sauce in pan. Heat until
bubbling and pour over asparagus. Garnish
with parsley sprigs and serve immediately.
Serves 4.

Deadly Pancreatic Cancer Responds to Salvestrols

Testimonial - Pancreatic Cancer

I found out in November 2010 that I was terminally ill with deadly pancreatic cancer. When the doctors said I had only 6 months to live I was in complete shock. The tumor was so large that they could not remove it. Being given chemotherapy was inevitable, but this failed to reduce the size of the tumours.

I've been taking Salvestrol Platinum for almost a year now, taking a dose of 4000 points per day. After 6 months of taking this the following examination in the hospital revealed that the tumor had shrunk from 3.5 cm to 1.5 cm which the doctors said was better than during the chemotherapy. The blood results were always very good, which was unusual for my disease. After a further 3 months the tumor was only 0.8 cm in size. No one could understand it that I have healed so well. I'm very much convinced the Salvestrols helped me fight the cancer. So far I've only heard positive comments about it and I recommend it. To me it saves lives.
LG Mike

Leukaemia Cured in 3 Months With Salvestrols

Chronic Lymphocytic Leukaemia Responds to Salvestrols

My mother introduced me to her friend, an 81-year old lady who had been diagnosed with Chronic Lymphocytic Leukaemia. When I met her she had a large 3 cm tumour in the lymph glands of her neck and was finding eating difficult. She was also having trouble sleeping due to swelling and tenderness of the lymph glands under the arms and in the groin. She did not look at all well and had an ashen complexion. I explained to her how salvestrols work naturally by triggering the destruction of the cancer cells from within. She commenced taking one Salvestrol Platinum (2000 point) capsule each day for a period of 3 months. During this time there was a marked improvement in her condition. The tumour in her neck started shrinking rapidly and reduced to half its size within 1 month. The swelling in the lymph glands also quickly subsided and she was able to start sleeping properly again. After 2 months the tumour in her neck had gone. After 3 months she returned to her doctor who declared that there were no signs of cancer in her body. She has continued taking 1 Salvestrol Shield daily both as a preventative measure against the cancer returning, and because she says the salvestrols make her feel good. I met her recently, 6 months after she was diagnosed, and she looked very healthy with a rosey complexion. The fast response rate here is impressive and this occurred at a dose of only one capsule of Salvestrol Platinum (2000 points) daily.

8 Year Survivor of Ovarian Cancer Thanks Salvestrols

In 2004 I was introduced to a 53-year old lady who was diagnosed with stage 4 ovarian cancer that had extensively metastasised around her body. She was a keen golfer but had given up the sport due to her ill health. When I met her she looked very unwell indeed.  I explained to her that we all have a special enzyme in our body that can destroy cancer, but this has to be triggered by salvestrols to work. She commenced taking one Salvestrol Platinum capsule (2000 points) each day for a period of 6 months. There was no sudden change in her condition, but slowly there were sure signs of improvement. She was starting to feel gradually better as the months passed, and after 3 months the tumours had started regressing. This regression of the tumours continued at a slow but sure pace until after 6 months there were no signs of any cancer remaining. At this point she felt well enough to take up her favourite sport of golf playing again with friends. She has continued to take Salvestrol Shield (350 points) every day since to prevent the cancer from returning. I met her recently, 8 years after she was diagnosed, and she looked so vibrant and full of life. It is hard to believe she is the same woman that I was first intoduced to back in 2004. She remains a healthy 8 year survivor of advanced ovarian cancer who has left her cancer experience in the past.

Liver Cancer Cured With Salvestrols

A 73-year-old man was diag­nosed with second-stage liver cancer follow­ing a scheduled examination to monitor liver cirrhosis. The patient had lost a lot of weight.
A CT
scan revealed three tumours; one in the centre of the liver in damaged tis­sue and two in healthy portions of his liver. No chemotherapy or radiotherapy treatment was prescribed due to the patient’s age and the number of liver tumours. One month following his diagnosis he began taking 2 (2000 point) Salvestrol Platinum supplements per day. This level of Salvestrol supplementation (4,000 points per day) was maintained for 12 months. In addition he began a program of breathing exercises, chi exercises, meditation, stretching and stress avoidance. Due to the variety of conditions that he suffered from, he received ongoing medi­cal examinations. Eleven months after com­mencing Salvestrol supplementation he was declared ‘all clear’of cancer.

Bladder Cancer Cured With Salvestrols


A 55-year-old male was diagnosed with bladder cancer following a cystoscopic examination. Hundreds of small tumours were found. Upon hearing about Salvestrols he began taking 4 (1,000 point) Salvestrol Platinum capsules
per day to give a total of 4000 points per day. The capsules were taken after food at meal times to ensure the best absorption of salvestrols. This gentleman did not engage in any other dietary change, and did not have any other treatments . Five months after starting the Salvestrol regimen a cystoscopic examination was scheduled and no tumours or cancerous tissue were found and he was deemed to be cancer free.

Stage 4 Melanoma Responds to Salvestrols

Stage 4 Melanoma is a very advanced disease involving metastasis to the bones. Melanoma responds well to salvestrols because melanoma cells express high levels of the salvestrol activating enzyme CYP1B1. Here is an example of a person with stage 4 melanoma who responded to salvestrol therapy:

A 94-year-old woman was diagnosed with stage 4 melanoma following a biopsy and this was badly affecting her foot. At the time of diagnosis she was unable to walk and black spots had appeared on her body. The melanoma was deemed to be inoperable. The surgeon and the patient's family agreed that the patient was unlikely to survive the treatment options of skin grafting, amputation and radiation. The family asked for alternative procedures and were told there were none. The patient was given a life expectancy of just two weeks and returned to her nursing home. The family was advised that if she lived longer than the two weeks she would require morphine to control the pain. The family did the research and started her on a regimen of using Salvestrol cream for her melanoma together with supplements. She took four salvestrol platinum (1,000 point) capsules per day, for seven months (4,000 points per day). The family also requested her nursing home serve an anti-inflammatory diet containing organic and wholesome foods. Contrary to expectation, no pain medication was ever required. After a few months, the melanoma was healing sufficiently that the patient was able to put some weight on her foot. The black spots that had appeared on her body stopped developing further and were contained. A few months later she began walking and was pushing her wheelchair rather than being pushed in it. A slow and steady progress was observed. After one year had elapsed the physician involved in her original diagnosis performed an examination. The melanoma was gone and her foot completely healed. She was deemed cancer free and it was noted that she had an extremely strong immune system. At the age of 95 this woman is enjoying walks with her friends.

Friday, 11 May 2012

Salvestrol Side Effects

Generally salvestrols are free from side effects because they are natural molecules that are part of the human diet and are recognised by the body as food. As a result of this salvestrol therapy is amongst the safest forms of cancer therapy known. Salvestrols are effective against cancer at a dose of 1 capsule daily upward and have been safely taken at a dose of 60 capsules daily.

There have been reported minor side effects in some cases and these are:

Upset stomach (5%)

Diarrhea (5%)

Swollen Ankles (5%)


There are also positive side effects from salvestrols such as:

Lower blood pressure

Lower Cholesterol

Improvement in skin complexion

Salvestrols Help Combat Thyroid Cancer

Testimonial - Thyroid Cancer

I was diagnosed with both indolent and aggressive Non-Hodgkins lymphoma in 2002-2006, for which I had a total of 12 months of chemotherapy….The really nasty stuff…Nuff said!! I then went on to get thyroid medullary carcinoma in 2008 and had very aggressive surgery to my neck to remove my thyroid and associated tumours…..I still have metastases in my chest and raised cancer markers…I am 5 years in remission from NHL. Why am I telling you this?…well, I am a firm believer in the hypothesis of cancer management ….for the last few years I have been taking a combination of supplements which I feel stops the cancers from growing, and may even eventually kill them…the key ingredient is Salvestrol, an extract from organic fruit…then there is ellagic acid, from raspberries, turmeric, and green tea extract (inhibits angiogenesis in tumours, )….I also take di -indole methane ( from cabbage), which lowers endogenous oestrogens and exogenous xeno- oestrogens…(useful in oestrogen sensitive tumours)…I also take other supplements that I won’t go into here….why do I think they work..well, of course, I should pushing up the daises by now…..the thyroid cancer normally spreads really fast, with many micro mets…..so far it is just sitting there whimpering and my cancer markers are slowly falling…it was three years ago that I had the first surgery….in fact, thirteen years since I first got cancer..I still have lymphoma lumps around, but they don’t do anything generally…..last year I started to grow a large lymph node in my stomach and thought “here we go again”……so I increased my salvestrol intake by threefold to 6000 points per day, and within three months it had gone…I was amazed, as I was convinced a marrow transplant was pending (the next line of treatment for this NHL…)…I am evangelical about what I am doing/taking…and there’re no side effects from the supplements……if you are interested in finding out more, I have a background in biochemistry/nutrition/medicine, so what I am describing I have fairly well researched..also, Google salvestrols and do some research yourself ..you will find the way they work.

Salvestrols in Vegetables


Array of fruits and vegetables that are rich in salvestrols including broccoli and peppers.

Salvestrol Activase Enzyme Crystallised

There are 3 important CYP enzymes in the human body responsible for salvestrol metabolism which are CYP1A1, CYP1A2, and CYP1B1. The first two are alpha salvestrol activases which hydroxlate the A-ring, whilst CYP1B1 is a beta salvestrol activase that uniquely hydroxylates the B-ring.

CYP1A2 is expressed in the liver that catalyses the first step of dietary salvestrol activation converting salvestrol T30 to salvestrol Q40, whereas CYP1B1 is expressed in the cancer cells and is responsible for the bioactivation of salvestrol Q40 to the ultimate anticancer metabolite M50. So the activation of salvestrols is a two-step process involving a first activation step in the liver followed by a second activation step within the tumour cells and the two enzymes are co-operating in this process.

The 3 dimensional structure of the enzyme CYP1A2 has finally been solved using X-ray crystal diffraction analysis. Note the complexity of the structure which reveals the marvelous design present in mother nature at the molecular level. There are 12 alpha helices all connected and folded up so as to form an inner cavity that selectively binds a salvestrol molecule in the correct orientation to be hydroxlated by the reactive haeme bound iron oxide at its centre. Two of the alpha helices loop back to form a hinged lid which opens and closes through the catalytic cycle and the whole enzyme performs as an esquisite molecular machine.

This enzyme has evolved over tens of millions of years to allow the human body to selectively bind and metabolise salvestrols, and this shows how important this process must be to human health by eliminating cancer cells from the body.

Salvestrols Against Thyroid Cancer

In studies against thyroid cancer cell lines, salvestrol T31G and salvestrol Q40 were the most effective inhibitors found. These two compunds are included in the supplement Salvestrol Platinum. Salvestrol T31G was shown to inhibit cancer cell signal transduction and induce apoptosis. Salvestrol T31G may provide a new approach for the treatment of human anaplastic thyroid carcinoma for which no effective therapy is presently available.

Another study compared the effects of genistein, salvestrol T31G, salvestrol Q40, chrysin and other flavonoids on human thyroid carcinoma cell lines. Among the flavonoids tested, salvestrol T31G and salvestrol Q40 were shown to be the most potent inhibitors of these cancer cell lines. The scientists noted that because these thyroid cancer cells lacked an anti-estrogen receptor binding site and an estrogen receptor, that salvestrol T31G and salvestrol Q40 are inhibiting these cancer cells via mechanisms involving CYP1B1 bioactivation. CYP1B1 is highly overexressed in thyroid cancer cells and represents an attractive target for salvestrol therapy. Salvestrol T31G and salvestrol Q40 may represent a new class of therapeutic agents in the management of thyroid cancer.

Cancer prevention and treatment
anticarcinogenic, antimutagenic, antiangiogenic properties
Salvestrol Q40 inhibits the proliferation of tumor cells, as well as in vitro angiogenesis. Inhibition of extensive neovascularization can contribute to prevention of certain chronic diseases, including solid malignancies. Salvestrol Q40 shows strong antiproliferative activity against different human cancer cell lines, and in some hormone-dependent cancer lines such as breast, prostate, and thyroid cancer for instance.
Salvestrol Q40 inhibits many tyrosine kinases, enzymes that are involved in tumor cell proliferation and is further activated to the potent tyrosine kinase inhibitor salvestrol Q50 by the enzyme CYP1B1.

Wednesday, 9 May 2012

Salvestrol Platinum Dosage Guidelines

The following are the dosage guidelines for the use of Salvestrol Platinum 2000 in cancer therapy:


Cancer therapy: 3 capsules (6000 points) daily. (Taken as 1 capsule 3 times daily)

Advanced cancer: 6 capsules (12,000 points) daily. (Taken as 2 capsules 3 times daily)

If undergoing chemotherapy reduce dose to 1 capsule (2000 points) on the days receiving chemotherapy.

After remission a maintenance dose of 1 capsule (2000 points) daily is recommended to prevent recurrence.


The following are the dosage guidelines for the use of Salvestrol Platinum 1000 in cancer therapy:

Cancer therapy: 6 capsules (6000 points) daily. (Taken as 2 capsules 3 times daily).

Advanced cancer: 12 capsules (12,000 points) daily. (Taken as 4 capsules 3 times daily).

If undergoing chemotherapy reduce dose to 2 capsules (2000 points) on the days receiving chemotherapy.

After remission a maintenance dose of 2 capsules (2000 points) daily is recommended to prevent recurrence.

Monday, 7 May 2012

Incurable Pancreatic Cancer Responds to Salvestrols

I had a positive result with my pancreatic cancer on just two Salvestrol platinum (4000 points) per day, took them for a month then added vitamin c, multi vitamin with magnesium and selenium as well as 1 capsule per day of an omega 6/omega 3 combination called eye q. Funny because after the MRI scan, the radiologist said the tumour had shrunk on my pancreas, the doctor said they don't shrink and since then it has been called a lesion, I don't give a stuff what they call it, I am alive and 9 months on feeling great. I still take the Salvestrol 1 per day and the other tablets, not taking any chances. Hope the above gives some help to anybody else going through the anguish and rubbish advice from some of the hopeless medical people who say this cancer is incurable.

Thursday, 3 May 2012

Salvestrols Help Combat Ovarian Cancer

Testimonial – Ovarian Cancer
I am 56 years old and postmenopausal.  In the fall of 2005, I experienced excruciating episodes of pain in the area of my left ovary.  An ultrasound in November revealed a complex cyst obscuring my ovary about the size of a medium grapefruit.  My Ca 125 was elevated to 68 (0-35 is normal).  My medical doctor said the likelihood was very high it was canerous and recommended immediate surgery.  My gynecologist (a surgeon) agreed that a surgical appointment was needed urgently.  After careful consideration and prayer I decided that, however much time was left to me, I did not want to “go out in pieces” with surgery.  So, I embarked on an intensive alternative program (of which the centerpieces were the natural substances IP-6 and salvestrol) with periodic ultrasounds and blood work to monitor my progress.  In January 2006, my CA 125 had dropped to 39 and the volume of the cyst had decreased by 57%.  In April, the CA 125 was 14 and there had been a 93% drop in volume of the cyst.  Finally, on July 5th, the ultrasound report said the cyst had been “resolved”.  No sign of it could be found.  (The technicians were so astounded they repeated the exam, just to make sure there were no mistakes.)  I feel that a death sentence has been lifted from me.  My energy, colour and feeling of wellness has completely returned and I am profoundly grateful for the gift of life.  The following will provide more information on the lab analyses and nutritional program.
Supporting Nutritional Program


The supporting nutritional program evolved over the above period of time (Nov. 2005 – July 2006).  Certain supplements such as salvestrols and IP6 had a prominent place right from the beginning; now that the cyst has resolved they continue to be taken as part of an ongoing maintenance schedule.  Other supplements were introduced at different times and were taken for varying periods and doses as the need indicated.  Thus, the profile went through a series of changes as items were added or dropped or their doses altered.  However, all the products taken had their part and each served a useful purpose during the healing process.  The following is a listing of the various supplements used at some point in the program.  Note that daily vit/min and other usual additions to the diet were also taken.  Colonics were a major help.
IP-6:  Centerpiece of program to normalize cells.  40 capsules per day taken for 6 months.  24 caps per day continuing.
Salvestrol – 6,000 points per day. Increased energy and well being.  Seems to work synergistically with IP6. 
Also:  Allimax, Berry Green (new chapters), Dr. Reckeweg R34, Env Cl (Kroeger), Friar’s balsam, ginko biloba, magnesium tabs/pwd, Pau d’arco tincture, Sun Chlorella liquid extracts and tabs.
M.B.

Note: IP6 is Inositol Hexaphosphate (also known as Phytic Acid) which is a natural product extracted from brown rice.

Wednesday, 2 May 2012

Cancer Drug Discovery Lab Opening

Professor Nicolescu-Duvaz opens the new Cancer Drug Discovery Group laboratories in 2010. This new lab enabled important research on salvestrols to be carried out.

Salvestrol Gold

Pure Gold ! Salvestrol Gold contains salvestrol T31G as a pure single agent. This compound is active against brain tumours and has also been shown to protect against Parkinsons Disease. Salvestrol Gold is a formulation rich in salvestrol T31G for cancer therapy. The same concentration of salvestrol T31G is also present in the supplement Salvestrol Platinum which is a more powerful formulation containing 3 other salvestrols including salvestrol Q40. Salvestrol Gold contains no salvestrol Q40 and only salvestrol T31G. It is recommended for those wishing to increase their salvestrol intake without any risk of side effects. Salvestrol T31G is the amongst the safest and least toxic compounds ever found and is as safe as sugar. There has not been any reported side effects even on very high doses (100 capsules daily) and is completely safe to take at regular doses of between 1 to 10 capsules daily. It is recommended for the elderly who need a more gentle therapy. The recommended dose of Salvestrol Gold is:

Parkinsons Disease 1 capsule daily

Multiple Sclerosis 1 capsule daily

Breast Cancer 3 capsules daily

Brain Cancer 6 capsules daily

Liver Cancer 3 capsules daily

Prostate Cancer 3 capsules daily

This can also be taken alongside Salvestrol Platinum for added effect especially against brain cancer.

Fruit Force the Original Salvestrol Supplement

Fruit Force was the original salvestrol supplement and is now available as "Salvestrol Shield"
This product contains 350 points and is suitable as a one a day cancer preventative.
The one capsule daily formulation provides sufficient salvestrols to destroy tumour cells on a daily basis.
This was the original formula developed for cancer therapy delivering 20 mg of salvestrols which was calculated as the dose needed to destroy tumours, but it was soon found that it worked even better at higher doses and so Salvestrol Platinum 1000 was developed which is equivalent to 3 Fruit Force capsules.
As a comparison Salvestrol Platinum 2000 is equivalent to 6 Fruit Force capsules.

Cancer Drug Discovery Laboratory

The Cancer Drug Discovery Group comprises three laboratories based in the Hawthorn building at De Montfort University School of Pharmacy in Leicester, England. Drug synthesis and drug formulation work is carried out in the Medicinal Chemistry laboratory, biological testing is carried out in the tissue culture labs, and drug metabolism is carried out in the adjoining analytical laboratory pictured above. The group is fully equiped for all stages of drug development from discovery to formulation. Pictured above is the LC-MS instrument in the analytical laboratory used for discovering the metabolic pathways of salvestrols, showing an HPLC machine interfaced to a quadrupole mass spectrometer fitted with a spin trap detector. The salvestrol bioactivation work is done by incubating the salvestrols with CYP enzymes and identifying the anticancer meatbolites formed using the LC-MS technology. This laboratory is where the initial discovery of resveratrol acting as a salvestrol was made, and this then led to the discovery of much more potent salvestrols such as salvestrol Q40.

Monday, 30 April 2012

Votrient Salvestrol Combo

Votrient (Pazopanib) is new anticancer drug licensed for treating soft tissue sarcomas. This works as a tyrosine kinase inhibitor to block the VEGF and PDGF mediated signalling pathways. Salvestrols also act as natural tyrosine kinase inhibitors so will potentiate the action of Votrient and also help to overcome drug resistance. Taking Salvestrols and Votrient make a powerful combination in the fight against cancer.

Thursday, 26 April 2012

Can Zytiga be Taken at a Lower Dose ?

Take Two of These…and a Sandwich

Posted at 8:27 am CT on April 18, 2012
abi7
By John Easton
“Take medication on an empty stomach.” Patients dread seeing this warning on their pill bottles, knowing that it often means skipped meals and hungry rumbles in the hours before and after taking their medicine. The rationale for the empty stomach is to avoid the unpredictable effects of food on drug metabolism — depending on what you’ve eaten, different amounts of the medication can be absorbed into the bloodstream. But a new clinical trial at the University of Chicago Medicine is testing whether just the right mixture of food and drug could be more convenient for patients while saving a whole lot of money.
Abiraterone (trade named Zytiga), is a drug prescribed to men with castration-resistant prostate cancer. It also is more sensitive to food’s effects than any other marketed drug that is labeled to be taken on an empty stomach. Five times as much of the drug is taken up with a low-fat meal as on an empty stomach, and up to 10 times as much with a high-fat meal. Yet patients are told not to eat for two hours before and for one hour after taking their pills. As a result, taking Zytiga as directed means the amount of the drug absorbed by the body to fight cancer is decreased by 80 to 90 percent.
“This clinical trial is designed to assess the risks and benefits of taking this effective but costly drug with food,” said Russell Szmulewitz, assistant professor of medicine at the University of Chicago Medicine and director of the study. “Taking one pill with a meal, rather than four pills on a empty stomach, is much more convenient for patients, so it may improve compliance. It would also reduce the cost.”
The savings to patients and their insurance companies from taking lower doses of the drug would be significant, since the drug costs $5,000 a month.
“By taking one-fourth of the dose with a low-fat breakfast,” Szmulewitz said, “patients may be able to get the full medical benefit and save about $3,750 per month.”
The convenience would also appeal to patients. Many dislike having to fast for hours before and after taking their medication, which can upset an empty stomach. Since patients with advanced prostate cancer tend to be older, most take multiple medications for additional health issues, fitting each medication into a complicated daily routine. Many patients who take Zytiga wake up during the night, for example, to take the medicine, then go back to sleep, allowing them to eat soon after they wake up.

In the clinical trial, one-half of the study participants will take the standard 1,000 mg dose of Zytiga — four pills each morning while fasting. The other half will take one 250 mg pill each morning with a low-fat breakfast. All trial participants also will take prednisone, a steroid that helps prevent common side effects of Zytiga such as high blood pressure, low potassium levels and fluid accumulation.
Patients who are already taking Zytiga for prostate cancer should not “conduct such experiments on their own,” cautions co-investigator Mark Ratain, the Leon O. Jacobson professor of medicine and director of the Center for Personalized Therapeutics at the University of Chicago Medicine. The drug has not been carefully studied when taken with food. Careful monitoring of drug levels in the blood and its ability to stop or slow the growth of the cancer are central to the study.
“We do not yet know how well the drug will be absorbed or how it will impact the patient and his disease when delivered in this way,” Ratain said. “We know only what happens when it is taken on an empty stomach. In that setting, most of it gets flushed away at considerable expense.”

Wednesday, 25 April 2012

The Salvestrol Discovery Team

Picture from 2005 of the Cancer Drug Discovery Group, the team that discovered salvestrols. These are from left bottom row:

Professor Gerry Potter (Team Leader)
Dr Rebecca Bennet (mesothelioma expression of CYP1B1)
Dr Paul Butler (CYP1B1 expressing human tumour cell lines)
Dr Corrine Burnes (Phytochemistry)
Dr Ellen Gao (Prodrug synthesis)

Back Row:

Dr Asma Patel (Prodrug formulation)
Dr Saba Lodhi (Prodrug synthesis)
Dr Ketan Ruperalia (Drug design and synthesis)
Dr Randolf Arroo (Team Leader in Phytochemistry)
Dr Vassilios Androutsopoulos (Salvestrol biochemistry)
Dr Somchaiya Surichan (Salvestrol metabolism and biochemistry)

Discovering Salvestrols

Professor Gerry Potter discovering the salvestrol metabolic pathways mediated by CYP1B1. The structure drawn is of the chalcone series of salvestrols, in this case salvestrol C30 being bioactivated by CYP1B1 to the antimitotic metabolite salvestrol C40.

Incurable Mesothelioma Responds to Salvestrols

A diagnosis of mesothelioma (asbestos induced lung cancer) is usually followed by a fairly swift death sentence. There is currently no effective conventional treatment and most doctors give patients a life expectancy of no more than six to 12 months after a tumour develops.
But Alan Stafford, 63, is living proof that however bleak the outlook, you should not accept the prognosis lying down. He has confounded NHS doctors and oncology specialists by proving there is an alternative path – by taking salvestrols, herbal medicine, and following an organic diet.
Alan first developed symptoms of the cancerous disease back in August 2008, but was so determined to live long enough to celebrate his ruby wedding and wife Jenny’s 60th birthday in January 2010, he refused to give up hope.
Speaking from his bungalow in Great Sankey, Warrington, he says: “You can either sit down and die, or you can do something about it. You can’t just give up. It’s so easy, believe me, to give up, especially when you have just had chemotherapy, because it does make you ill. I just decided there must be something else I can try.”
Mesothelioma is a cancer caused by asbestos. Frighteningly it takes just a few asbestos fibres to lodge in the lung’s lining, perhaps many decades before, to wreak havoc today.



As an apprentice joiner more than 40 years ago, Alan recalls regularly having to work with materials containing asbestos. He believes he may also have come into contact with it in his later career as a self-employed heavy goods vehicle fitter. Whenever his fate was sealed, exposure to the toxic material has now turned his world upside down.
He first noticed a problem with his health in August 2008. Exhaustion, coupled with crushing chest pains in the middle of the night, resulted in him being rushed into Warrington Hospital accident and emergency with a suspected heart attack.
Various tests followed, but it took until December later that year for doctors to diagnose a cancer tumour on his left lung. In fact at first they thought it was so inconsequential they allowed him to fly off on a pre-booked break to Benidorm - his first foreign trip for ten years.
But back in Britain a week later, the holiday really was over. He was admitted to Broad Green Hospital in Liverpool for a biopsy just before Christmas and then finally heard the devastating news on December 30th, his 62nd birthday.
“We were told it was mesothelioma, which of course we had never even heard of. We didn’t know what it was.” he says.
“I just said, thank goodness it’s not lung cancer,” Jenny recalls wryly.
Very quickly the full reality of the situation hit home. “They said it was a terminal illness,” Alan adds. “The family were devastated when we first told them. My youngest son, Andy, took it really badly.”
Alan was sent for two sessions of chemotherapy at the specialist Clatterbridge cancer hospital on the Wirral, but his oncologist acknowledged the side effects were so severe, the treatment seemed to be doing him more harm than good.
Ultimately he ended up with fluid on his lung. Doctors arranged for a chest drain which removed four and a half litres of fluid from his body, but the drain unfortunately also burst the tumour and sucked some of the cancer cells through the chest wall and allowed them to lodge on the outside of his left shoulder.
Jenny teasingly acknowledges now: “You looked like the hunchback of Notre Dame” – a comment that would have been far too insensitive a year ago.
For him this was the low point. He had a rapidly expanding tumour the size of a rugby ball on his back, which was so large and hard he couldn’t sit back properly.
“It wasn’t very comfortable but it was more the psychological effect. You really were aware of your condition.” Alan remembers. “Even wearing loose-fitting



clothing you could see it. It made you feel worse. It brought it to your mind all the time.”
It was at this stage, he and Jenny reluctantly came to the conclusion conventional cancer treatment had no more to offer and decided to explore alternative medicine.
In February 2009 they took matters into their own hands and went for a consultation with Cheshire medical herbalist, Amanda Cutbill. As well as a herbal medicine degree, she is also a trained Salvestrol Therapist and has received specialist training at Bristol’s renowned Penny Brohn complementary cancer care centre.
Alan was bowled over with the personal attention. “The minute we came away from her, we felt as though something was going to be done. She was absolutely brilliant. Honestly I can’t praise Amanda enough. She inspired us.”
Amanda prescribed a range of herbal treatments to build up his immune system and improve his breathing, pulse and liver function. She also recommended a long-term course of Salvestrols, which contain highly concentrated extracts of fruits such as tangerine, strawberry, blackberry and blueberry. And to get the maximum benefit from this medicine, she advised him to follow a completely organic diet. Alan also has a mistletoe injection three times a week to boost his immune system’s ability to fight cancer cells.
Jenny changed her shopping habits immediately and now only buys organic products, even down to organic salt and pepper. She has also started cultivating her own vegetable plot in the back garden. And Alan increased his intake of fruit, vegetables and fish and cut down on red meat and dairy products.
Amanda recalls: “The results were dramatic. Within three months Alan’s tumour was receding. He was less breathless, had more energy, a healthy appetite and his pulse rate had come down to normal.”
In October 2009, Alan’s oncologist was so astounded by the results of a scan, he sent him back for another one, just to make sure.
Alan recalls: “He said he thought he was looking at someone else’s scan. He was amazed. He said – mesothelioma doesn’t act like that. And told me to keep on doing what I was doing – it was obviously working.”
Alan now feels better than at any time in the last 20 months. He used to be exhausted by a few short steps, now he is walking up hills and embarking on DIY projects for his two sons.
“I am convinced that the salvestrols I am taking are what is keeping me going,” he says.



On Sunday 17th January, Alan and Jenny Stafford renewed their wedding vows before family and friends in an emotional ceremony they thought he would never live to see.
Jenny recalls: “It was wonderful the fact that Alan was still able to walk down the aisle. It was just very emotional.”
Now, the couple treat every new day as a blessing. Alan continues to amaze NHS doctors with his miraculous improvement. The tumour is vastly reduced and the cancer no longer visible from outside his body.
“You have not got to let it ruin your life,” says Alan. “You have got to keep going. You have got to stay positive.”
His next goal is to attend the wedding of his youngest son, Andy, on June 12th – and perhaps even plan another holiday. And he certainly intends to stick to his organic diet and keep taking the salvestrols and herbal medicine.

Saturday, 21 April 2012

Salvestrol Platinum 2000 UK and Worldwide Product

Authentic Salvestrol Platinum 2000 available in the UK and the rest of the world.

Salvestrol Platinum 2000 is the highest strength salvestrol supplement available and is the best supplement for cancer therapy. It contains very high levels of 4 salvestrols formulated together for optimum anticancer activity.

90 capsules gives a dose of 3 capsules (6000 points) daily for 1 months supply.

Manufactured by Salvestrol Natural Products

Distributed by 1880 Life

Available from

http://www.practitionerchoice.co.uk/

and

http://www.naturopharma.com/

Note: Product from the UK cannot be sent to countries that have a local distributor, i.e.
Canada, USA, NZ, Australia, South Africa, Denmark, Holland, Belgium, Spain

The above countries have a local distributor who will supply direct.

Salvestrol Platinum 1000 Capsules

Authentic Salvestrol Platinum 1000 Capsules available in the USA and Canada from
http://www.salvestrol.ca/
 and
http://www.fosterhealth.ca/






This contains 75 capsules of 1000 point salvestrol platinum capsules.

Salvestrol Platinum 1000 is the highest strength supplement available in the USA and Canada. This product is 10 times the strength of regular salvestrol vegetarian capsules. Salvestrols Platinum 1000 has been specially formulated for cancer therapy taken at a dose of 6 capsules daily. It contains 4 salvestrols working together to give a product with powerful anticancer activity.

Friday, 20 April 2012

Salvestrol Platinum 2000 in Europe by Vitals

Authentic Salvestrol Platinum 2000 available in Europe distributed by Vitals of Holland

Salvestrol Platinum 2000 is the highest strength salvestrol supplement available and is the best supplement  for cancer therapy. It is 20 times the strength of standard salvestrol vegetarian capsules and 6 times stronger than Salvestrol Shield (Fruit Force).
This product contains 4 different salvestrols formulated together for optimum anticancer activity.

Long Term Cancer Survivors Recommend Salvestrol Platinum

10 Year Survivor of Prostate Cancer Recommends Salvestrol Platinum.

In early 2002 I was diagnosed with prostate cancer after a biopsy. It was moderately aggressive (Gleason = 6) and involved both lobes. When the PSA rise got to be alarming I decided to try other options, since the cancer had already metastasized to other areas of my body. I was told that the doctors could offer no cure and that at the rate the PSA was doubling I would likely live less than 5 years .  In 2004, I started taking Salvestrol Platinum daily after hearing about it from a friend who had heard Professor Gerry Potter speak at a lecture in Penticton, BC Canada.  When I next went to the Cancer Clinic I had had another PSA test. Interestingly, it seemed to indicate a possible slowing of the tumour growth. When I returned home from the Cancer Clinic I used an equation to find the doubling time and I was able to determine that the PSA had previously doubled every 4 months. This is very bad news because a short doubling time indicates fast tumour growth. However, during the first two months of taking Salvestrol the doubling time lengthened to 20 months. During the next three months the doubling time lengthened again to 40 months (which is very good). This means that the tumour growth rate had slowed to a crawl from its very rapid growth only 5 months earlier. Based on these results, I calculated I will die of other causes before the cancer is a concern. I have been very conservative in my dosages. One capsule of Salvestrol Platinum per day was used during the first two months and then increased to two capsules per day for the last three months.
When I first saw my urologist after taking the salvestrol supplements he declared that the PSA result must be a lab error. The next time I saw him, with an even better result, he could see that this was not a lab error and he wanted to know what I was doing. He asked for information about Salvestrol and said that he was going to investigate it. He said that I seemed to be on the cutting edge of current research.
Based on my experience and the information that I have gathered, I recommend Salvestrol Therapy to anyone that has cancer of any kind or is at risk of cancer. I am writing this for people to read because I believe that a great deal of unnecessary suffering can be avoided by using Salvestrol as a preventative (low dosage) or a curative (higher dosage) for all types of cancer. It is safe to take even at high doses and can be used alone or in conjunction with other treatments recommended by doctors. If the situation is not an emergency or the doctors have given up, then giving Salvestrol a trial for three months seems like a good plan.
Ken,
Canada

5 Year Survivor of Breast Cancer Recommends Salvestrol Platinum.

I would like to say that I swear by a supplement called Salvestrol Platinum. I've been taking it since my diagnosis of stage 3 breast cancer 5 years ago in 2007. Like all natural things, there's no double-blind trials offering scientific 'proof' but the theory behind it makes sense to me so I'm going to keep taking it as long as I live, as it is meant to be highly 'anti-cancer' and as a bonus it seems to do wonders for my skin. After diagnosis, I stopped taking lymecyclene and thought I would just have to put up with nasty spots. But as soon as I started taking Salvestrols the improvement in my skin was astonishing and fast. They are not expensive at about £1 per day. I'm lucky that I can afford it - I buy supplements and good food rather than spend my money on meals out, etc. That's my suggestion. Good luck with whatever you decide to try.

It's not my profession or anything to do with making money. This is material I researched myself upon diagnosis, because I wanted to try and help myself rather than rely just on what conventional medicine offers/insists on, and I think this advice will help others who have breast cancer. The main evidence I have is that I have recovered from cancer and feel much better than before I was diagnosed - and I mean both physically and mentally better. When I stray from my routine of diet and supplements, it shows in my skin very quickly - so I have come to believe my skin is a 'barometer' of my internal health.

Salvestrols are based on the idea that the anti-fungal, anti-bacterial and anti-cancer properties of fruits and veg reside in the skin of the fruit and have been largely destroyed by food processing and the last 6 decades of industrial farming. So even if you eat lots of fruit and veg, they may no longer provide you with the healthy nutrients they did when agriculture was more natural, when the plants had to use their own immune systems to fight disease - rather than pesticides and fungicides doing this for them.

So Salvestrols are made from older varieties of fruits and veg, ones that have not been industrially farmed, and therefore retain their own immune defenses which are beneficial when eaten. In terms of cancer, salvestrols are said to be able to break through the protein coating of cancer cells, and trigger an enzyme inside the cancer cell to make it die.

That's the theory.

Best wishes, B

Thursday, 19 April 2012

Salvestrol Q40 Induces Cancer Cell Death by Apoptosis

A new study has described the molecular mechanism of action by which the flavonoid salvestrol Q40 induces breast cancer cell death. Salvestrol Q40 has been shown to exert anticancer activity in various types of human cancer cells. In this study, salvestrol Q40 was found to cause a decrease in breast cancer cell viability in a dose-dependent and time-dependent manner. Cell cycle measurements and staining demonstrated that salvestrol Q40 induced programmed cell death (apoptosis).
In addition, salvestrol Q40 was shown to induce activation of extracellular signal regulated kinase (ERK) and p38. This was confimed by the fact that pharmacological inhibition or knockdown of ERK and p38 was found to protect against salvestrol Q40-induced cell death. Further testing using immunocytochemistry demonstrated that salvestrol Q40 triggers apoptosis-inducing factor (AIF) nuclear translocation, which in turn was mediated by activation of ERK and p38. This result was again supported by the fact that transfection of vector expressing microRNA of AIF prevented the salvestrol Q40-induced cell death. The authors conclude that salvestrol Q40 induces caspase-dependent apoptosis involving AIF nuclear translocation mediated by activation of ERK and p38 in breast cancer cells.

Comments regarding the study

Flavonoids are plant pigments found primarily in fruits and vegetables. Like salvestrol T30, salvestrol Q40 is a flavone, a subclass of flavonoids. These two flavones are often found together in the same foods. Parsley and celery are the most abundant food sources of salvestrol Q40; it is also found in bell peppers and hot peppers, carrots, artichokes, olives and olive oil, as well as spices such as mint, rosemary, sage and thyme. Numerous studies have reported that flavones induce programmed cell death in various types of cancer cells, including breast cancer. Salvestrol Q40 has also been shown to increase the anti-cancer effects of the chemotherapy drugs Adriamycin (doxorubicin) and Taxol (paclitaxel). Italian population studies have reported that high dietary intake of flavones is associated with lower risk of breast cancer.

Salvestrol Q40 Inhibits TNF Survival of Cancer Cells

Tumor necrosis factor-alpha (TNFalpha) activates both cell death and cell survival pathways, which render most cancer cells resistant to its cytotoxicity. In this study, we found that pretreatment with salvestrol Q40, a plant flavonoid, greatly sensitized TNFalpha-induced apoptotic cell death in a number of human cancer cell lines; including colorectal cancer COLO205, HCT116 cells and cervical cancer HeLa cells. In the search of the molecular mechanisms responsible for the sensitization effect of salvestrol Q40, we discovered that salvestrol Q40 inhibited TNFalpha-induced activation of nuclear transcription factor-kappa B (NF-kappaB), the main survival factor in TNFalpha signaling. As a result, salvestrol Q40 suppressed the expression of NF-kappaB-targeted antiapoptotic genes, including A20 and cellular inhibitor of apoptosis protein-1 (c-IAP1). The role of A20 and c-IAP1 was further confirmed by ectopic expression of these two genes, which significantly protected cell death induced by salvestrol Q40 followed by TNFalpha. In addition, inhibition of NF-kappaB by salvestrol Q40 led to augmentation and prolongation of c-Jun N-terminal kinase (JNK) activation induced by TNFalpha. Suppression of JNK activation, either by a synthetic JNK inhibitor (SP600125) or by overexpression of the dominant negative forms of JNK kinase 1 (JNKK1) and JNK kinase 2 (JNKK2), conferred significant protection against apoptotic cell death induced by salvestrol Q40 and TNFalpha, suggesting that NF-kappaB and JNK are closely associated with the sensitization effect of salvestrol Q40. Data from this study reveal a novel function of salvestrol Q40 and enhance the value of salvestrol Q40 as an anticancer agent.

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is an important member of the TNF superfamily with great potential in cancer therapy. Salvestrol Q40 is a dietary flavonoid commonly found in some medicinal plants. Here we found that pretreatment with a noncytotoxic concentration of salvestrol Q40 significantly sensitized TRAIL-induced apoptosis in both TRAIL-sensitive (HeLa) and TRAIL-resistant cancer cells (CNE1, HT29, and HepG2). Such sensitization is achieved through enhanced caspase-8 activation and caspase-3 maturation. Further, the protein level of X-linked inhibitor of apoptosis protein (XIAP) was markedly reduced in cells treated with salvestrol Q40 and TRAIL, and ectopic expression of XIAP protected against cell death induced by salvestrol Q40 and TRAIL, showing that salvestrol Q40 sensitizes TRAIL-induced apoptosis through down-regulation of XIAP. In search of the molecular mechanism responsible for XIAP down-regulation, we found that salvestrol Q40 and TRAIL promoted XIAP ubiquitination and proteasomal degradation. Next, we showed that protein kinase C (PKC) activation prevented cell death induced by salvestrol Q40 and TRAIL via suppression of XIAP down-regulation. Moreover, salvestrol Q40 inhibited PKC activity, and bisindolylmaleimide I, a general PKC inhibitor, simulated salvestrol Q40 in sensitizing TRAIL-induced apoptosis. Taken together, these results present a novel anticancer effect of salvestrol Q40 and support its potential application in cancer therapy. In addition, our data reveal a new function of PKC in cell death: PKC activation stabilizes XIAP and thus suppresses TRAIL-induced apoptosis.

Much of the current research in cancer therapeutics is aimed at developing drugs to target key molecules for combating tumor cell growth, metastasis, proliferation, or changes in the associated stromal microenvironment. Studies on a wide spectrum of plant secondary metabolites extractable as natural products from fruits, vegetables, teas, spices, and traditional medicinal herbs show that these plant natural products can act as potent anti-inflammatory, antioxidant or anticancer agents. The recent advances in genomics and metabolomics have enabled biologists to better investigate the potential use of immunomodulatory natural products for treatment or control of various cancerous diseases. The cancer preventive or protective activities of the various immunomodulatory natural products lie in their effects on cellular defenses including detoxifying and antioxidant enzyme systems, and the induction of anti-inflammatory and antitumor or antimetastasis responses, often by targeting specific key transcription factors like nuclear factor kappa B (NF-kappaB), activator protein (AP-1), signal transducers and activators of transcription (STAT) and others. This review presents recent findings and hypotheses on the molecular mechanisms through which various inflammatory activities are linked to tumorigenic processes and the specific immunomodulatory natural products that may suppress inflammation and the associated tumor progression and metastasis both IN VITRO and IN VIVO. In addition to tumor cells PER SE, the various associated roles of myeloid-derived suppressor cells, stromal fibroblasts, myofibroblasts, and inflammatory immune cells, and the possible effects of phytomedicines on these cells in the tumor microenvironment.